Gene Name
|
Gene ID
|
Diseases
|
Drugs
|
GO terms
|
Orthologs
|
TOP2B
|
ENSG00000077097
|
No diseases in record
|
ETOPOSIDE
TENIPOSIDE
|
chromatin binding
DNA topoisomerase type II (ATP-hydrolyzing) activity
protein kinase C binding
ATP binding
protein C-terminus binding
DNA binding, bending
enzyme binding
histone deacetylase binding
metal ion binding
protein heterodimerization activity
|
TOP2 (S. cerevisiae)
cin-4 (C. elegans)
top-2 (C. elegans)
|
TOP1
|
ENSG00000198900
|
AML*
|
IRINOTECAN
|
core promoter sequence-specific DNA binding
DNA binding
chromatin binding
DNA topoisomerase type I activity
protein binding
isomerase activity
DNA topoisomerase activity
|
TOP1 (S. cerevisiae)
top-1 (C. elegans)
Top1 (D. melanogaster)
|