TOP2B

ENSG00000077097 - H. sapiens

Pathways

Go term Description
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042826 histone deacetylase binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
ETOPOSIDE DNA topoisomerase II inhibitor
TENIPOSIDE DNA topoisomerase II inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000077097 TOP2B ENSG00000172531 PPP1CA H. sapiens SSL Slorth 0.888018 View
ENSG00000077097 TOP2B ENSG00000158828 PINK1 H. sapiens SSL Slorth 0.887966 View
ENSG00000077097 TOP2B ENSG00000135341 MAP3K7 H. sapiens SSL Slorth 0.887907 View
ENSG00000006451 RALA ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.887777 View
ENSG00000077097 TOP2B ENSG00000135829 DHX9 H. sapiens SSL Slorth 0.887645 View
ENSG00000077097 TOP2B ENSG00000105401 CDC37 H. sapiens SSL Slorth 0.887499 View
ENSG00000077097 TOP2B ENSG00000149311 ATM H. sapiens SSL Slorth 0.887119 View
ENSG00000051382 PIK3CB ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.8871 View
ENSG00000077097 TOP2B ENSG00000185651 UBE2L3 H. sapiens SSL Slorth 0.886938 View
ENSG00000077097 TOP2B ENSG00000144028 SNRNP200 H. sapiens SSL Slorth 0.886934 View
ENSG00000077097 TOP2B ENSG00000165025 SYK H. sapiens SSL Slorth 0.886883 View
ENSG00000077097 TOP2B ENSG00000166598 HSP90B1 H. sapiens SSL Slorth 0.886825 View
ENSG00000077097 TOP2B ENSG00000095015 MAP3K1 H. sapiens SSL Slorth 0.886778 View
ENSG00000077097 TOP2B ENSG00000254087 LYN H. sapiens SSL Slorth 0.886677 View
ENSG00000077097 TOP2B ENSG00000110092 CCND1 H. sapiens SSL Slorth 0.886621 View
ENSG00000077097 TOP2B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.886534 View
ENSG00000077097 TOP2B ENSG00000147274 RBMX H. sapiens SSL Slorth 0.885614 View
ENSG00000077097 TOP2B ENSG00000185345 PARK2 H. sapiens SSL Slorth 0.885339 View
ENSG00000077097 TOP2B ENSG00000100644 HIF1A H. sapiens SSL Slorth 0.885158 View
ENSG00000077097 TOP2B ENSG00000196470 SIAH1 H. sapiens SSL Slorth 0.885156 View
ENSG00000077097 TOP2B ENSG00000159692 CTBP1 H. sapiens SSL Slorth 0.884701 View
ENSG00000077097 TOP2B ENSG00000169047 IRS1 H. sapiens SSL Slorth 0.884686 View
ENSG00000077097 TOP2B ENSG00000198793 MTOR H. sapiens SSL Slorth 0.884626 View
ENSG00000077097 TOP2B ENSG00000253729 PRKDC H. sapiens SSL Slorth 0.883806 View
ENSG00000077097 TOP2B ENSG00000156970 BUB1B H. sapiens SSL Slorth 0.883257 View
ENSG00000077097 TOP2B ENSG00000166197 NOLC1 H. sapiens SSL Slorth 0.882796 View
ENSG00000077097 TOP2B ENSG00000141646 SMAD4 H. sapiens SSL Slorth 0.882468 View
ENSG00000077097 TOP2B ENSG00000196419 XRCC6 H. sapiens SSL Slorth 0.882118 View
ENSG00000077097 TOP2B ENSG00000096717 SIRT1 H. sapiens SSL Slorth 0.881935 View
ENSG00000077097 TOP2B ENSG00000175197 DDIT3 H. sapiens SSL Slorth 0.8818 View
ENSG00000077097 TOP2B ENSG00000170365 SMAD1 H. sapiens SSL Slorth 0.881739 View
ENSG00000071051 NCK2 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.881621 View
ENSG00000051180 RAD51 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.881179 View
ENSG00000072803 FBXW11 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.880751 View
ENSG00000077097 TOP2B ENSG00000117676 RPS6KA1 H. sapiens SSL Slorth 0.880494 View
ENSG00000077097 TOP2B ENSG00000131508 UBE2D2 H. sapiens SSL Slorth 0.88032 View
ENSG00000077097 TOP2B ENSG00000127511 SIN3B H. sapiens SSL Slorth 0.880219 View
ENSG00000077097 TOP2B ENSG00000124762 CDKN1A H. sapiens SSL Slorth 0.879827 View
ENSG00000077097 TOP2B ENSG00000157933 SKI H. sapiens SSL Slorth 0.879784 View
ENSG00000077097 TOP2B ENSG00000170004 CHD3 H. sapiens SSL Slorth 0.879505 View