TOP2B

ENSG00000077097 - H. sapiens

Pathways

Go term Description
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042826 histone deacetylase binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
ETOPOSIDE DNA topoisomerase II inhibitor
TENIPOSIDE DNA topoisomerase II inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000077097 TOP2B ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.862627 View
ENSG00000077097 TOP2B ENSG00000108312 UBTF H. sapiens SSL Slorth 0.862416 View
ENSG00000077097 TOP2B ENSG00000097046 CDC7 H. sapiens SSL Slorth 0.862386 View
ENSG00000077097 TOP2B ENSG00000196591 HDAC2 H. sapiens SSL Slorth 0.862239 View
ENSG00000050820 BCAR1 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.86202 View
ENSG00000077097 TOP2B ENSG00000166501 PRKCB H. sapiens SSL Slorth 0.861701 View
ENSG00000077097 TOP2B ENSG00000164885 CDK5 H. sapiens SSL Slorth 0.861495 View
ENSG00000077097 TOP2B ENSG00000101266 CSNK2A1 H. sapiens SSL Slorth 0.861458 View
ENSG00000077097 TOP2B ENSG00000082701 GSK3B H. sapiens SSL Slorth 0.861366 View
ENSG00000077097 TOP2B ENSG00000112118 MCM3 H. sapiens SSL Slorth 0.860613 View
ENSG00000077097 TOP2B ENSG00000088832 FKBP1A H. sapiens SSL Slorth 0.860219 View
ENSG00000077097 TOP2B ENSG00000100028 SNRPD3 H. sapiens SSL Slorth 0.859421 View
ENSG00000077097 TOP2B ENSG00000175104 TRAF6 H. sapiens SSL Slorth 0.859019 View
ENSG00000077097 TOP2B ENSG00000178568 ERBB4 H. sapiens SSL Slorth 0.85822 View
ENSG00000077097 TOP2B ENSG00000089685 BIRC5 H. sapiens SSL Slorth 0.857749 View
ENSG00000077097 TOP2B ENSG00000112592 TBP H. sapiens SSL Slorth 0.857606 View
ENSG00000053900 ANAPC4 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.857032 View
ENSG00000077097 TOP2B ENSG00000087586 AURKA H. sapiens SSL Slorth 0.856092 View
ENSG00000077097 TOP2B ENSG00000137693 YAP1 H. sapiens SSL Slorth 0.855758 View
ENSG00000075089 ACTR6 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.855399 View
ENSG00000077097 TOP2B ENSG00000166851 PLK1 H. sapiens SSL Slorth 0.855305 View
ENSG00000077097 TOP2B ENSG00000105568 PPP2R1A H. sapiens SSL Slorth 0.855133 View
ENSG00000077097 TOP2B ENSG00000077150 NFKB2 H. sapiens SSL Slorth 0.854882 View
ENSG00000077097 TOP2B ENSG00000130522 JUND H. sapiens SSL Slorth 0.853541 View
ENSG00000072110 ACTN1 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.852894 View
ENSG00000077097 TOP2B ENSG00000166949 SMAD3 H. sapiens SSL Slorth 0.852685 View
ENSG00000077097 TOP2B ENSG00000100722 ZC3H14 H. sapiens SSL Slorth 0.852537 View
ENSG00000077097 TOP2B ENSG00000116288 PARK7 H. sapiens SSL Slorth 0.852442 View
ENSG00000077097 TOP2B ENSG00000124216 SNAI1 H. sapiens SSL Slorth 0.851427 View
ENSG00000077097 TOP2B ENSG00000106211 HSPB1 H. sapiens SSL Slorth 0.85136 View
ENSG00000077097 TOP2B ENSG00000113013 HSPA9 H. sapiens SSL Slorth 0.850903 View
ENSG00000077097 TOP2B ENSG00000169967 MAP3K2 H. sapiens SSL Slorth 0.849743 View
ENSG00000077097 TOP2B ENSG00000153147 SMARCA5 H. sapiens SSL Slorth 0.849462 View
ENSG00000077097 TOP2B ENSG00000093009 CDC45 H. sapiens SSL Slorth 0.848169 View
ENSG00000077097 TOP2B ENSG00000163161 ERCC3 H. sapiens SSL Slorth 0.847995 View
ENSG00000077097 TOP2B ENSG00000089737 DDX24 H. sapiens SSL Slorth 0.847219 View
ENSG00000077097 TOP2B ENSG00000117748 RPA2 H. sapiens SSL Slorth 0.846569 View
ENSG00000077097 TOP2B ENSG00000185591 SP1 H. sapiens SSL Slorth 0.845163 View
ENSG00000077097 TOP2B ENSG00000159259 CHAF1B H. sapiens SSL Slorth 0.844611 View
ENSG00000077097 TOP2B ENSG00000100813 ACIN1 H. sapiens SSL Slorth 0.843793 View