TOP2B

ENSG00000077097 - H. sapiens

Pathways

Go term Description
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042826 histone deacetylase binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
ETOPOSIDE DNA topoisomerase II inhibitor
TENIPOSIDE DNA topoisomerase II inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000077097 TOP2B ENSG00000164362 TERT H. sapiens SSL Slorth 0.843319 View
ENSG00000077097 TOP2B ENSG00000132155 RAF1 H. sapiens SSL Slorth 0.843262 View
ENSG00000077097 TOP2B ENSG00000132341 RAN H. sapiens SSL Slorth 0.8431 View
ENSG00000077097 TOP2B ENSG00000149136 SSRP1 H. sapiens SSL Slorth 0.843056 View
ENSG00000077097 TOP2B ENSG00000118503 TNFAIP3 H. sapiens SSL Slorth 0.842952 View
ENSG00000002016 RAD52 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.842811 View
ENSG00000076555 ACACB ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.842731 View
ENSG00000077097 TOP2B ENSG00000198909 MAP3K3 H. sapiens SSL Slorth 0.842512 View
ENSG00000076984 MAP2K7 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.842239 View
ENSG00000077097 TOP2B ENSG00000094804 CDC6 H. sapiens SSL Slorth 0.841913 View
ENSG00000077097 TOP2B ENSG00000100138 SNU13 H. sapiens SSL Slorth 0.841231 View
ENSG00000077097 TOP2B ENSG00000183765 CHEK2 H. sapiens SSL Slorth 0.840606 View
ENSG00000077097 TOP2B ENSG00000111276 CDKN1B H. sapiens SSL Slorth 0.84044 View
ENSG00000077097 TOP2B ENSG00000129559 NEDD8 H. sapiens SSL Slorth 0.840401 View
ENSG00000077097 TOP2B ENSG00000100030 MAPK1 H. sapiens SSL Slorth 0.840067 View
ENSG00000077097 TOP2B ENSG00000142208 AKT1 H. sapiens SSL Slorth 0.839343 View
ENSG00000013503 POLR3B ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.839321 View
ENSG00000077097 TOP2B ENSG00000184634 MED12 H. sapiens SSL Slorth 0.839192 View
ENSG00000077097 TOP2B ENSG00000197122 SRC H. sapiens SSL Slorth 0.838887 View
ENSG00000017797 RALBP1 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.838223 View
ENSG00000077097 TOP2B ENSG00000165280 VCP H. sapiens SSL Slorth 0.837498 View
ENSG00000077097 TOP2B ENSG00000126561 STAT5A H. sapiens SSL Slorth 0.837232 View
ENSG00000077097 TOP2B ENSG00000100811 YY1 H. sapiens SSL Slorth 0.836624 View
ENSG00000077097 TOP2B ENSG00000102554 KLF5 H. sapiens SSL Slorth 0.836393 View
ENSG00000072310 SREBF1 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.83603 View
ENSG00000039068 CDH1 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.835423 View
ENSG00000077097 TOP2B ENSG00000180370 PAK2 H. sapiens SSL Slorth 0.835063 View
ENSG00000077097 TOP2B ENSG00000163938 GNL3 H. sapiens SSL Slorth 0.83476 View
ENSG00000077097 TOP2B ENSG00000163930 BAP1 H. sapiens SSL Slorth 0.834595 View
ENSG00000077097 TOP2B ENSG00000170142 UBE2E1 H. sapiens SSL Slorth 0.834319 View
ENSG00000077097 TOP2B ENSG00000133703 KRAS H. sapiens SSL Slorth 0.833764 View
ENSG00000077097 TOP2B ENSG00000198087 CD2AP H. sapiens SSL Slorth 0.833401 View
ENSG00000077097 TOP2B ENSG00000196235 SUPT5H H. sapiens SSL Slorth 0.833352 View
ENSG00000077097 TOP2B ENSG00000101412 E2F1 H. sapiens SSL Slorth 0.833336 View
ENSG00000077097 TOP2B ENSG00000148606 POLR3A H. sapiens SSL Slorth 0.832455 View
ENSG00000077097 TOP2B ENSG00000112249 ASCC3 H. sapiens SSL Slorth 0.831682 View
ENSG00000077097 TOP2B ENSG00000163041 H3F3A H. sapiens SSL Slorth 0.830816 View
ENSG00000068078 FGFR3 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.8306 View
ENSG00000077097 TOP2B ENSG00000100387 RBX1 H. sapiens SSL Slorth 0.830292 View
ENSG00000077097 TOP2B ENSG00000113658 SMAD5 H. sapiens SSL Slorth 0.829646 View