TOP2B

ENSG00000077097 - H. sapiens

Pathways

Go term Description
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042826 histone deacetylase binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
ETOPOSIDE DNA topoisomerase II inhibitor
TENIPOSIDE DNA topoisomerase II inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000077097 TOP2B ENSG00000136628 EPRS H. sapiens SSL Slorth 0.8792 View
ENSG00000077097 TOP2B ENSG00000100462 PRMT5 H. sapiens SSL Slorth 0.879054 View
ENSG00000077097 TOP2B ENSG00000167085 PHB H. sapiens SSL Slorth 0.878183 View
ENSG00000077097 TOP2B ENSG00000094916 CBX5 H. sapiens SSL Slorth 0.877481 View
ENSG00000077097 TOP2B ENSG00000177606 JUN H. sapiens SSL Slorth 0.87744 View
ENSG00000068024 HDAC4 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.876811 View
ENSG00000077097 TOP2B ENSG00000154229 PRKCA H. sapiens SSL Slorth 0.876493 View
ENSG00000072518 MARK2 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.876141 View
ENSG00000077097 TOP2B ENSG00000126261 UBA2 H. sapiens SSL Slorth 0.8756 View
ENSG00000077097 TOP2B ENSG00000198625 MDM4 H. sapiens SSL Slorth 0.875556 View
ENSG00000077097 TOP2B ENSG00000148400 NOTCH1 H. sapiens SSL Slorth 0.875543 View
ENSG00000049759 NEDD4L ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.874872 View
ENSG00000077097 TOP2B ENSG00000101868 POLA1 H. sapiens SSL Slorth 0.874758 View
ENSG00000077097 TOP2B ENSG00000125630 POLR1B H. sapiens SSL Slorth 0.87407 View
ENSG00000077097 TOP2B ENSG00000172053 QARS H. sapiens SSL Slorth 0.874063 View
ENSG00000077097 TOP2B ENSG00000175792 RUVBL1 H. sapiens SSL Slorth 0.873866 View
ENSG00000075785 RAB7A ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.873125 View
ENSG00000077097 TOP2B ENSG00000104365 IKBKB H. sapiens SSL Slorth 0.873053 View
ENSG00000077097 TOP2B ENSG00000188486 H2AFX H. sapiens SSL Slorth 0.871037 View
ENSG00000077097 TOP2B ENSG00000134308 YWHAQ H. sapiens SSL Slorth 0.871014 View
ENSG00000077097 TOP2B ENSG00000101945 SUV39H1 H. sapiens SSL Slorth 0.870697 View
ENSG00000077097 TOP2B ENSG00000147133 TAF1 H. sapiens SSL Slorth 0.870631 View
ENSG00000010017 RANBP9 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.87031 View
ENSG00000077097 TOP2B ENSG00000117399 CDC20 H. sapiens SSL Slorth 0.870096 View
ENSG00000077097 TOP2B ENSG00000109971 HSPA8 H. sapiens SSL Slorth 0.869517 View
ENSG00000077097 TOP2B ENSG00000096968 JAK2 H. sapiens SSL Slorth 0.869459 View
ENSG00000077097 TOP2B ENSG00000121022 COPS5 H. sapiens SSL Slorth 0.869379 View
ENSG00000026103 FAS ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.869253 View
ENSG00000077097 TOP2B ENSG00000164754 RAD21 H. sapiens SSL Slorth 0.869131 View
ENSG00000077097 TOP2B ENSG00000113575 PPP2CA H. sapiens SSL Slorth 0.867496 View
ENSG00000077097 TOP2B ENSG00000122512 PMS2 H. sapiens SSL Slorth 0.867264 View
ENSG00000077097 TOP2B ENSG00000186868 MAPT H. sapiens SSL Slorth 0.866217 View
ENSG00000077097 TOP2B ENSG00000151247 EIF4E H. sapiens SSL Slorth 0.865187 View
ENSG00000077097 TOP2B ENSG00000141027 NCOR1 H. sapiens SSL Slorth 0.864222 View
ENSG00000077097 TOP2B ENSG00000173039 RELA H. sapiens SSL Slorth 0.864016 View
ENSG00000077097 TOP2B ENSG00000113712 CSNK1A1 H. sapiens SSL Slorth 0.864011 View
ENSG00000077097 TOP2B ENSG00000100823 APEX1 H. sapiens SSL Slorth 0.863823 View
ENSG00000077097 TOP2B ENSG00000100201 DDX17 H. sapiens SSL Slorth 0.86382 View
ENSG00000077097 TOP2B ENSG00000121481 RNF2 H. sapiens SSL Slorth 0.863153 View
ENSG00000077097 TOP2B ENSG00000108984 MAP2K6 H. sapiens SSL Slorth 0.862795 View