TOP2B

ENSG00000077097 - H. sapiens

Pathways

Go term Description
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042826 histone deacetylase binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
ETOPOSIDE DNA topoisomerase II inhibitor
TENIPOSIDE DNA topoisomerase II inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000074181 NOTCH3 ENSG00000077097 TOP2B H. sapiens SDL Slorth 0.907838 View
ENSG00000077097 TOP2B ENSG00000092201 SUPT16H H. sapiens SDL Slorth 0.907812 View
ENSG00000064012 CASP8 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.907749 View
ENSG00000077097 TOP2B ENSG00000198648 STK39 H. sapiens SDL Slorth 0.907618 View
ENSG00000077097 TOP2B ENSG00000104738 MCM4 H. sapiens SSL Slorth 0.907617 View
ENSG00000077097 TOP2B ENSG00000169756 LIMS1 H. sapiens SDL Slorth 0.907597 View
ENSG00000072736 NFATC3 ENSG00000077097 TOP2B H. sapiens SDL Slorth 0.90746 View
ENSG00000077097 TOP2B ENSG00000198677 TTC37 H. sapiens SDL Slorth 0.907406 View
ENSG00000077097 TOP2B ENSG00000123136 DDX39A H. sapiens SDL Slorth 0.90734 View
ENSG00000077097 TOP2B ENSG00000143258 USP21 H. sapiens SDL Slorth 0.907328 View
ENSG00000077097 TOP2B ENSG00000138814 PPP3CA H. sapiens SDL Slorth 0.906916 View
ENSG00000077097 TOP2B ENSG00000110713 NUP98 H. sapiens SDL Slorth 0.906747 View
ENSG00000077097 TOP2B ENSG00000170836 PPM1D H. sapiens SDL Slorth 0.906722 View
ENSG00000077097 TOP2B ENSG00000244405 ETV5 H. sapiens SDL Slorth 0.906535 View
ENSG00000077097 TOP2B ENSG00000096384 HSP90AB1 H. sapiens SSL Slorth 0.906312 View
ENSG00000077097 TOP2B ENSG00000099817 POLR2E H. sapiens SDL Slorth 0.906207 View
ENSG00000077097 TOP2B ENSG00000085276 MECOM H. sapiens SDL Slorth 0.9054 View
ENSG00000077097 TOP2B ENSG00000109332 UBE2D3 H. sapiens SSL Slorth 0.905397 View
ENSG00000077097 TOP2B ENSG00000145349 CAMK2D H. sapiens SDL Slorth 0.905353 View
ENSG00000077097 TOP2B ENSG00000157106 SMG1 H. sapiens SSL Slorth 0.905319 View
ENSG00000077097 TOP2B ENSG00000168385 SEPT2 H. sapiens SDL Slorth 0.905216 View
ENSG00000077097 TOP2B ENSG00000173039 RELA H. sapiens SDL Slorth 0.904989 View
ENSG00000077097 TOP2B ENSG00000173120 KDM2A H. sapiens SDL Slorth 0.904711 View
ENSG00000077097 TOP2B ENSG00000123374 CDK2 H. sapiens SDL Slorth 0.904698 View
ENSG00000067560 RHOA ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.904633 View
ENSG00000077097 TOP2B ENSG00000135144 DTX1 H. sapiens SDL Slorth 0.904556 View
ENSG00000077097 TOP2B ENSG00000131759 RARA H. sapiens SSL Slorth 0.904536 View
ENSG00000077097 TOP2B ENSG00000176248 ANAPC2 H. sapiens SDL Slorth 0.904455 View
ENSG00000077097 TOP2B ENSG00000115677 HDLBP H. sapiens SDL Slorth 0.904302 View
ENSG00000077097 TOP2B ENSG00000100906 NFKBIA H. sapiens SSL Slorth 0.903949 View
ENSG00000077097 TOP2B ENSG00000122566 HNRNPA2B1 H. sapiens SDL Slorth 0.90385 View
ENSG00000077097 TOP2B ENSG00000127152 BCL11B H. sapiens SDL Slorth 0.903748 View
ENSG00000077097 TOP2B ENSG00000143799 PARP1 H. sapiens SSL Slorth 0.903582 View
ENSG00000077097 TOP2B ENSG00000166333 ILK H. sapiens SDL Slorth 0.903568 View
ENSG00000023445 BIRC3 ENSG00000077097 TOP2B H. sapiens SSL Slorth 0.903481 View
ENSG00000077097 TOP2B ENSG00000117020 AKT3 H. sapiens SDL Slorth 0.903395 View
ENSG00000077097 TOP2B ENSG00000126457 PRMT1 H. sapiens SSL Slorth 0.903332 View
ENSG00000077097 TOP2B ENSG00000100297 MCM5 H. sapiens SDL Slorth 0.903318 View
ENSG00000077097 TOP2B ENSG00000105810 CDK6 H. sapiens SSL Slorth 0.903299 View
ENSG00000077097 TOP2B ENSG00000165806 CASP7 H. sapiens SDL Slorth 0.903259 View