TOP2B - NOTCH1

H. sapiens

SSL interaction

Identifiers

Gene Name Gene ID Diseases Drugs GO terms Orthologs
TOP2B ENSG00000077097

No diseases in record

ETOPOSIDE
TENIPOSIDE
chromatin binding
DNA topoisomerase type II (ATP-hydrolyzing) activity
protein kinase C binding
ATP binding
protein C-terminus binding
DNA binding, bending
enzyme binding
histone deacetylase binding
metal ion binding
protein heterodimerization activity
TOP2 (S. cerevisiae)
cin-4 (C. elegans)
top-2 (C. elegans)
NOTCH1 ENSG00000148400 T-ALL
breast
bladder
skin SCC
lung SCC
head and neck SCC

No drugs in record

core promoter binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
enzyme inhibitor activity
receptor activity
Notch binding
calcium ion binding
protein binding
enzyme binding
chromatin DNA binding
sequence-specific DNA binding
protein heterodimerization activity
N (D. melanogaster)