TOP2B - SMAD5

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TOP2B	ENSG00000077097	No diseases in record	ETOPOSIDE TENIPOSIDE	chromatin binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein kinase C binding ATP binding protein C-terminus binding DNA binding, bending enzyme binding histone deacetylase binding metal ion binding protein heterodimerization activity	TOP2 (S. cerevisiae) cin-4 (C. elegans) top-2 (C. elegans)
SMAD5	ENSG00000113658	No diseases in record	No drugs in record	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding signal transducer activity, downstream of receptor protein binding transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ubiquitin protein ligase binding metal ion binding	sma-3 (C. elegans) sma-2 (C. elegans)