POLE

ENSG00000177084 - H. sapiens

Pathways

Go term Description
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0051539 4 iron, 4 sulfur cluster binding

Drugs

Drug name Description
CLOFARABINE DNA inhibitor
CYTARABINE DNA polymerase (alpha/delta/epsilon) inhibitor
FLUDARABINE PHOSPHATE DNA polymerase (alpha/delta/epsilon) inhibitor
GEMCITABINE

Diseases

Disease Name
colorectal carcinoma
endometrioid carcinoma
stomach carcinoma
skin cancer
colorectal cancer susceptibility

Orthologs

Gene Organism
POL2 S. cerevisiae
pole-1 C. elegans
DNApol-epsilon255 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000177084 POLE ENSG00000254087 LYN H. sapiens SSL Slorth 0.916535 View
ENSG00000154229 PRKCA ENSG00000177084 POLE H. sapiens SSL Slorth 0.916045 View
ENSG00000123124 WWP1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.915785 View
ENSG00000109906 ZBTB16 ENSG00000177084 POLE H. sapiens SSL Slorth 0.915355 View
ENSG00000105810 CDK6 ENSG00000177084 POLE H. sapiens SSL Slorth 0.915083 View
ENSG00000177084 POLE ENSG00000185345 PARK2 H. sapiens SSL Slorth 0.914779 View
ENSG00000177084 POLE ENSG00000244687 UBE2V1 H. sapiens SSL Slorth 0.914331 View
ENSG00000177084 POLE ENSG00000185651 UBE2L3 H. sapiens SSL Slorth 0.914259 View
ENSG00000177084 POLE ENSG00000185787 MORF4L1 H. sapiens SSL Slorth 0.914209 View
ENSG00000177084 POLE ENSG00000198353 HOXC4 H. sapiens SDL Slorth 0.914158 View
ENSG00000177084 POLE ENSG00000183431 SF3A3 H. sapiens SSL Slorth 0.914108 View
ENSG00000177084 POLE ENSG00000183207 RUVBL2 H. sapiens SSL Slorth 0.913985 View
ENSG00000177084 POLE ENSG00000196591 HDAC2 H. sapiens SSL Slorth 0.913616 View
ENSG00000177084 POLE ENSG00000184634 MED12 H. sapiens SSL Slorth 0.913557 View
ENSG00000141480 ARRB2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.913515 View
ENSG00000177084 POLE ENSG00000197299 BLM H. sapiens SSL Slorth 0.913046 View
ENSG00000117399 CDC20 ENSG00000177084 POLE H. sapiens SSL Slorth 0.91303 View
ENSG00000177084 POLE ENSG00000273841 TAF9 H. sapiens SSL Slorth 0.912987 View
ENSG00000077097 TOP2B ENSG00000177084 POLE H. sapiens SDL Slorth 0.912697 View
ENSG00000113575 PPP2CA ENSG00000177084 POLE H. sapiens SDL Slorth 0.912465 View
ENSG00000121774 KHDRBS1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.912459 View
ENSG00000177084 POLE ENSG00000187555 USP7 H. sapiens SSL Slorth 0.912383 View
ENSG00000137486 ARRB1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.912247 View
ENSG00000080815 PSEN1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.912107 View
ENSG00000091831 ESR1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.911994 View
ENSG00000177084 POLE ENSG00000204103 MAFB H. sapiens SDL Slorth 0.911989 View
ENSG00000103275 UBE2I ENSG00000177084 POLE H. sapiens SSL Slorth 0.911206 View
ENSG00000166888 STAT6 ENSG00000177084 POLE H. sapiens SSL Slorth 0.911184 View
ENSG00000177084 POLE ENSG00000181163 NPM1 H. sapiens SSL Slorth 0.911053 View
ENSG00000075624 ACTB ENSG00000177084 POLE H. sapiens SSL Slorth 0.910529 View
ENSG00000112062 MAPK14 ENSG00000177084 POLE H. sapiens SDL Slorth 0.910508 View
ENSG00000177084 POLE ENSG00000182866 LCK H. sapiens SSL Slorth 0.910488 View
ENSG00000164362 TERT ENSG00000177084 POLE H. sapiens SDL Slorth 0.910358 View
ENSG00000174231 PRPF8 ENSG00000177084 POLE H. sapiens SDL Slorth 0.910167 View
ENSG00000121481 RNF2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.909779 View
ENSG00000164885 CDK5 ENSG00000177084 POLE H. sapiens SDL Slorth 0.90902 View
ENSG00000154229 PRKCA ENSG00000177084 POLE H. sapiens SDL Slorth 0.908987 View
ENSG00000177084 POLE ENSG00000206181 TCEB3B H. sapiens SDL Slorth 0.908699 View
ENSG00000177084 POLE ENSG00000177981 ASB8 H. sapiens SDL Slorth 0.908699 View
ENSG00000010810 FYN ENSG00000177084 POLE H. sapiens SDL Slorth 0.908404 View