POLE

ENSG00000177084 - H. sapiens

Pathways

Go term Description
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0051539 4 iron, 4 sulfur cluster binding

Drugs

Drug name Description
CLOFARABINE DNA inhibitor
CYTARABINE DNA polymerase (alpha/delta/epsilon) inhibitor
FLUDARABINE PHOSPHATE DNA polymerase (alpha/delta/epsilon) inhibitor
GEMCITABINE

Diseases

Disease Name
colorectal carcinoma
endometrioid carcinoma
stomach carcinoma
skin cancer
colorectal cancer susceptibility

Orthologs

Gene Organism
POL2 S. cerevisiae
pole-1 C. elegans
DNApol-epsilon255 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000128245 YWHAH ENSG00000177084 POLE H. sapiens SSL Slorth 0.895798 View
ENSG00000175387 SMAD2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.895362 View
ENSG00000167513 CDT1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.8953 View
ENSG00000063244 U2AF2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.895138 View
ENSG00000135624 CCT7 ENSG00000177084 POLE H. sapiens SSL Slorth 0.894815 View
ENSG00000111276 CDKN1B ENSG00000177084 POLE H. sapiens SSL Slorth 0.893868 View
ENSG00000121022 COPS5 ENSG00000177084 POLE H. sapiens SSL Slorth 0.893647 View
ENSG00000136450 SRSF1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.892528 View
ENSG00000087586 AURKA ENSG00000177084 POLE H. sapiens SSL Slorth 0.892231 View
ENSG00000111875 ASF1A ENSG00000177084 POLE H. sapiens SSL Slorth 0.892173 View
ENSG00000023445 BIRC3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.892116 View
ENSG00000164924 YWHAZ ENSG00000177084 POLE H. sapiens SSL Slorth 0.891992 View
ENSG00000154473 BUB3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.891937 View
ENSG00000177084 POLE ENSG00000196235 SUPT5H H. sapiens SSL Slorth 0.89193 View
ENSG00000002016 RAD52 ENSG00000177084 POLE H. sapiens SSL Slorth 0.891741 View
ENSG00000177084 POLE ENSG00000198625 MDM4 H. sapiens SSL Slorth 0.891614 View
ENSG00000106462 EZH2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.890692 View
ENSG00000142208 AKT1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.890631 View
ENSG00000114166 KAT2B ENSG00000177084 POLE H. sapiens SSL Slorth 0.89008 View
ENSG00000127337 YEATS4 ENSG00000177084 POLE H. sapiens SSL Slorth 0.890018 View
ENSG00000159461 AMFR ENSG00000177084 POLE H. sapiens SSL Slorth 0.889665 View
ENSG00000124762 CDKN1A ENSG00000177084 POLE H. sapiens SSL Slorth 0.889443 View
ENSG00000177084 POLE ENSG00000179262 RAD23A H. sapiens SSL Slorth 0.888385 View
ENSG00000112062 MAPK14 ENSG00000177084 POLE H. sapiens SSL Slorth 0.8878 View
ENSG00000166851 PLK1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.887251 View
ENSG00000132383 RPA1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.88691 View
ENSG00000117133 RPF1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.886888 View
ENSG00000163932 PRKCD ENSG00000177084 POLE H. sapiens SSL Slorth 0.886738 View
ENSG00000171132 PRKCE ENSG00000177084 POLE H. sapiens SSL Slorth 0.886693 View
ENSG00000116044 NFE2L2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.885225 View
ENSG00000116030 SUMO1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.884257 View
ENSG00000132155 RAF1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.883974 View
ENSG00000164305 CASP3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.883862 View
ENSG00000133316 WDR74 ENSG00000177084 POLE H. sapiens SSL Slorth 0.883526 View
ENSG00000169750 RAC3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.883443 View
ENSG00000134086 VHL ENSG00000177084 POLE H. sapiens SSL Slorth 0.883328 View
ENSG00000177084 POLE ENSG00000198668 CALM1 H. sapiens SSL Slorth 0.882903 View
ENSG00000131747 TOP2A ENSG00000177084 POLE H. sapiens SSL Slorth 0.882551 View
ENSG00000127022 CANX ENSG00000177084 POLE H. sapiens SSL Slorth 0.882468 View
ENSG00000177084 POLE ENSG00000198742 SMURF1 H. sapiens SSL Slorth 0.88225 View