POLE

ENSG00000177084 - H. sapiens

Pathways

Go term Description
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0051539 4 iron, 4 sulfur cluster binding

Drugs

Drug name Description
CLOFARABINE DNA inhibitor
CYTARABINE DNA polymerase (alpha/delta/epsilon) inhibitor
FLUDARABINE PHOSPHATE DNA polymerase (alpha/delta/epsilon) inhibitor
GEMCITABINE

Diseases

Disease Name
colorectal carcinoma
endometrioid carcinoma
stomach carcinoma
skin cancer
colorectal cancer susceptibility

Orthologs

Gene Organism
POL2 S. cerevisiae
pole-1 C. elegans
DNApol-epsilon255 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000135486 HNRNPA1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.965556 View
ENSG00000169375 SIN3A ENSG00000177084 POLE H. sapiens SSL Slorth 0.965467 View
ENSG00000132383 RPA1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.965373 View
ENSG00000097007 ABL1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.96126 View
ENSG00000139687 RB1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.960664 View
ENSG00000149311 ATM ENSG00000177084 POLE H. sapiens SDL Slorth 0.960217 View
ENSG00000141646 SMAD4 ENSG00000177084 POLE H. sapiens SSL Slorth 0.958589 View
ENSG00000055130 CUL1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.958291 View
ENSG00000101146 RAE1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.958134 View
ENSG00000175104 TRAF6 ENSG00000177084 POLE H. sapiens SSL Slorth 0.957092 View
ENSG00000173039 RELA ENSG00000177084 POLE H. sapiens SDL Slorth 0.955652 View
ENSG00000168496 FEN1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.955484 View
ENSG00000170312 CDK1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.955412 View
ENSG00000097007 ABL1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.95449 View
ENSG00000177084 POLE ENSG00000185591 SP1 H. sapiens SDL Slorth 0.953379 View
ENSG00000136997 MYC ENSG00000177084 POLE H. sapiens SSL Slorth 0.952812 View
ENSG00000109320 NFKB1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.952679 View
ENSG00000110395 CBL ENSG00000177084 POLE H. sapiens SSL Slorth 0.951856 View
ENSG00000005339 CREBBP ENSG00000177084 POLE H. sapiens SSL Slorth 0.951615 View
ENSG00000110092 CCND1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.950585 View
ENSG00000164305 CASP3 ENSG00000177084 POLE H. sapiens SDL Slorth 0.949885 View
ENSG00000166949 SMAD3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.9495 View
ENSG00000167552 TUBA1A ENSG00000177084 POLE H. sapiens SSL Slorth 0.949299 View
ENSG00000004700 RECQL ENSG00000177084 POLE H. sapiens SSL Slorth 0.949232 View
ENSG00000177084 POLE ENSG00000177606 JUN H. sapiens SDL Slorth 0.949211 View
ENSG00000012048 BRCA1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.948699 View
ENSG00000100644 HIF1A ENSG00000177084 POLE H. sapiens SDL Slorth 0.948214 View
ENSG00000143799 PARP1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.947823 View
ENSG00000094804 CDC6 ENSG00000177084 POLE H. sapiens SSL Slorth 0.946998 View
ENSG00000169083 AR ENSG00000177084 POLE H. sapiens SSL Slorth 0.946185 View
ENSG00000149311 ATM ENSG00000177084 POLE H. sapiens SSL Slorth 0.945344 View
ENSG00000162231 NXF1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.945321 View
ENSG00000166167 BTRC ENSG00000177084 POLE H. sapiens SDL Slorth 0.94514 View
ENSG00000177084 POLE ENSG00000177885 GRB2 H. sapiens SDL Slorth 0.944625 View
ENSG00000149136 SSRP1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.944272 View
ENSG00000073111 MCM2 ENSG00000177084 POLE H. sapiens SDL Slorth 0.943349 View
ENSG00000177084 POLE ENSG00000197122 SRC H. sapiens SDL Slorth 0.942946 View
ENSG00000177084 POLE ENSG00000188612 SUMO2 H. sapiens SDL Slorth 0.942819 View
ENSG00000173039 RELA ENSG00000177084 POLE H. sapiens SSL Slorth 0.942705 View
ENSG00000136518 ACTL6A ENSG00000177084 POLE H. sapiens SSL Slorth 0.942111 View