POLE

ENSG00000177084 - H. sapiens

Pathways

Go term Description
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0051539 4 iron, 4 sulfur cluster binding

Drugs

Drug name Description
CLOFARABINE DNA inhibitor
CYTARABINE DNA polymerase (alpha/delta/epsilon) inhibitor
FLUDARABINE PHOSPHATE DNA polymerase (alpha/delta/epsilon) inhibitor
GEMCITABINE

Diseases

Disease Name
colorectal carcinoma
endometrioid carcinoma
stomach carcinoma
skin cancer
colorectal cancer susceptibility

Orthologs

Gene Organism
POL2 S. cerevisiae
pole-1 C. elegans
DNApol-epsilon255 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000177084 POLE ENSG00000221983 UBA52 H. sapiens SDL Slorth 0.907453 View
ENSG00000065559 MAP2K4 ENSG00000177084 POLE H. sapiens SSL Slorth 0.907247 View
ENSG00000093009 CDC45 ENSG00000177084 POLE H. sapiens SSL Slorth 0.907125 View
ENSG00000123374 CDK2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.907103 View
ENSG00000177084 POLE ENSG00000184937 WT1 H. sapiens SDL Slorth 0.907012 View
ENSG00000101966 XIAP ENSG00000177084 POLE H. sapiens SDL Slorth 0.906591 View
ENSG00000121879 PIK3CA ENSG00000177084 POLE H. sapiens SSL Slorth 0.906491 View
ENSG00000177084 POLE ENSG00000196470 SIAH1 H. sapiens SSL Slorth 0.906477 View
ENSG00000165280 VCP ENSG00000177084 POLE H. sapiens SDL Slorth 0.906166 View
ENSG00000084774 CAD ENSG00000177084 POLE H. sapiens SDL Slorth 0.906029 View
ENSG00000004897 CDC27 ENSG00000177084 POLE H. sapiens SSL Slorth 0.905822 View
ENSG00000177084 POLE ENSG00000178568 ERBB4 H. sapiens SSL Slorth 0.905752 View
ENSG00000085840 ORC1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.905629 View
ENSG00000131759 RARA ENSG00000177084 POLE H. sapiens SSL Slorth 0.905611 View
ENSG00000148400 NOTCH1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.904525 View
ENSG00000175054 ATR ENSG00000177084 POLE H. sapiens SSL Slorth 0.904279 View
ENSG00000114423 CBLB ENSG00000177084 POLE H. sapiens SSL Slorth 0.903781 View
ENSG00000006451 RALA ENSG00000177084 POLE H. sapiens SSL Slorth 0.903544 View
ENSG00000177084 POLE ENSG00000198793 MTOR H. sapiens SSL Slorth 0.90322 View
ENSG00000177084 POLE ENSG00000184012 TMPRSS2 H. sapiens SDL Slorth 0.903174 View
ENSG00000157764 BRAF ENSG00000177084 POLE H. sapiens SSL Slorth 0.902923 View
ENSG00000141736 ERBB2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.902888 View
ENSG00000140464 PML ENSG00000177084 POLE H. sapiens SSL Slorth 0.902462 View
ENSG00000082701 GSK3B ENSG00000177084 POLE H. sapiens SSL Slorth 0.902035 View
ENSG00000092201 SUPT16H ENSG00000177084 POLE H. sapiens SSL Slorth 0.901883 View
ENSG00000132341 RAN ENSG00000177084 POLE H. sapiens SSL Slorth 0.901568 View
ENSG00000140992 PDPK1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.901439 View
ENSG00000121022 COPS5 ENSG00000177084 POLE H. sapiens SDL Slorth 0.90133 View
ENSG00000117748 RPA2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.900918 View
ENSG00000172531 PPP1CA ENSG00000177084 POLE H. sapiens SDL Slorth 0.900909 View
ENSG00000108424 KPNB1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.900695 View
ENSG00000058729 RIOK2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.900018 View
ENSG00000177084 POLE ENSG00000185697 MYBL1 H. sapiens SDL Slorth 0.900004 View
ENSG00000167986 DDB1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.89919 View
ENSG00000101266 CSNK2A1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.899101 View
ENSG00000166501 PRKCB ENSG00000177084 POLE H. sapiens SSL Slorth 0.897841 View
ENSG00000151247 EIF4E ENSG00000177084 POLE H. sapiens SSL Slorth 0.897496 View
ENSG00000177084 POLE ENSG00000187608 ISG15 H. sapiens SSL Slorth 0.897459 View
ENSG00000078140 UBE2K ENSG00000177084 POLE H. sapiens SSL Slorth 0.89736 View
ENSG00000117676 RPS6KA1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.89734 View