POLE

ENSG00000177084 - H. sapiens

Pathways

Go term Description
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0051539 4 iron, 4 sulfur cluster binding

Drugs

Drug name Description
CLOFARABINE DNA inhibitor
CYTARABINE DNA polymerase (alpha/delta/epsilon) inhibitor
FLUDARABINE PHOSPHATE DNA polymerase (alpha/delta/epsilon) inhibitor
GEMCITABINE

Diseases

Disease Name
colorectal carcinoma
endometrioid carcinoma
stomach carcinoma
skin cancer
colorectal cancer susceptibility

Orthologs

Gene Organism
POL2 S. cerevisiae
pole-1 C. elegans
DNApol-epsilon255 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000135341 MAP3K7 ENSG00000177084 POLE H. sapiens SSL Slorth 0.800046 View
ENSG00000164045 CDC25A ENSG00000177084 POLE H. sapiens SSL Slorth 0.799654 View
ENSG00000125952 MAX ENSG00000177084 POLE H. sapiens SSL Slorth 0.799268 View
ENSG00000064995 TAF11 ENSG00000177084 POLE H. sapiens SSL Slorth 0.798829 View
ENSG00000177084 POLE ENSG00000197122 SRC H. sapiens SSL Slorth 0.798711 View
ENSG00000120438 TCP1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.797989 View
ENSG00000170365 SMAD1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.797848 View
ENSG00000177084 POLE ENSG00000178999 AURKB H. sapiens SSL Slorth 0.795976 View
ENSG00000130811 EIF3G ENSG00000177084 POLE H. sapiens SSL Slorth 0.795859 View
ENSG00000145715 RASA1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.795796 View
ENSG00000104695 PPP2CB ENSG00000177084 POLE H. sapiens SSL Slorth 0.793702 View
ENSG00000104852 SNRNP70 ENSG00000177084 POLE H. sapiens SSL Slorth 0.793618 View
ENSG00000150459 SAP18 ENSG00000177084 POLE H. sapiens SSL Slorth 0.790889 View
ENSG00000051382 PIK3CB ENSG00000177084 POLE H. sapiens SSL Slorth 0.790821 View
ENSG00000094631 HDAC6 ENSG00000177084 POLE H. sapiens SSL Slorth 0.79049 View
ENSG00000077063 CTTNBP2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.789558 View
ENSG00000280548 FBL ENSG00000177084 POLE H. sapiens SSL Slorth 0.789211 View
ENSG00000177084 POLE ENSG00000178950 GAK H. sapiens SSL Slorth 0.788627 View
ENSG00000176105 YES1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.788433 View
ENSG00000171720 HDAC3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.787011 View
ENSG00000112531 QKI ENSG00000177084 POLE H. sapiens SSL Slorth 0.784598 View
ENSG00000066468 FGFR2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.784261 View
ENSG00000149923 PPP4C ENSG00000177084 POLE H. sapiens SSL Slorth 0.784185 View
ENSG00000173020 GRK2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.783663 View
ENSG00000148606 POLR3A ENSG00000177084 POLE H. sapiens SSL Slorth 0.783551 View
ENSG00000166598 HSP90B1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.783361 View
ENSG00000165392 WRN ENSG00000177084 POLE H. sapiens SSL Slorth 0.781732 View
ENSG00000102572 STK24 ENSG00000177084 POLE H. sapiens SSL Slorth 0.781033 View
ENSG00000096401 CDC5L ENSG00000177084 POLE H. sapiens SSL Slorth 0.780433 View
ENSG00000050820 BCAR1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.779805 View
ENSG00000115053 NCL ENSG00000177084 POLE H. sapiens SSL Slorth 0.779397 View
ENSG00000065427 KARS ENSG00000177084 POLE H. sapiens SSL Slorth 0.779213 View
ENSG00000118007 STAG1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.777251 View
ENSG00000168438 CDC40 ENSG00000177084 POLE H. sapiens SSL Slorth 0.776868 View
ENSG00000130985 UBA1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.774665 View
ENSG00000110107 PRPF19 ENSG00000177084 POLE H. sapiens SSL Slorth 0.774525 View
ENSG00000140396 NCOA2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.774391 View
ENSG00000134602 STK26 ENSG00000177084 POLE H. sapiens SSL Slorth 0.774104 View
ENSG00000170345 FOS ENSG00000177084 POLE H. sapiens SSL Slorth 0.773615 View
ENSG00000100906 NFKBIA ENSG00000177084 POLE H. sapiens SSL Slorth 0.772515 View