POLE

ENSG00000177084 - H. sapiens

Pathways

Go term Description
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0051539 4 iron, 4 sulfur cluster binding

Drugs

Drug name Description
CLOFARABINE DNA inhibitor
CYTARABINE DNA polymerase (alpha/delta/epsilon) inhibitor
FLUDARABINE PHOSPHATE DNA polymerase (alpha/delta/epsilon) inhibitor
GEMCITABINE

Diseases

Disease Name
colorectal carcinoma
endometrioid carcinoma
stomach carcinoma
skin cancer
colorectal cancer susceptibility

Orthologs

Gene Organism
POL2 S. cerevisiae
pole-1 C. elegans
DNApol-epsilon255 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141564 RPTOR ENSG00000177084 POLE H. sapiens SSL Slorth 0.881758 View
ENSG00000134853 PDGFRA ENSG00000177084 POLE H. sapiens SSL Slorth 0.881621 View
ENSG00000168496 FEN1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.881523 View
ENSG00000113712 CSNK1A1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.880824 View
ENSG00000176208 ATAD5 ENSG00000177084 POLE H. sapiens SSL Slorth 0.880728 View
ENSG00000169679 BUB1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.880522 View
ENSG00000080503 SMARCA2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.879653 View
ENSG00000145604 SKP2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.878647 View
ENSG00000157106 SMG1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.878391 View
ENSG00000103479 RBL2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.877721 View
ENSG00000096717 SIRT1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.877535 View
ENSG00000080824 HSP90AA1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.877487 View
ENSG00000085511 MAP3K4 ENSG00000177084 POLE H. sapiens SSL Slorth 0.876944 View
ENSG00000085840 ORC1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.876665 View
ENSG00000114767 RRP9 ENSG00000177084 POLE H. sapiens SSL Slorth 0.876381 View
ENSG00000132964 CDK8 ENSG00000177084 POLE H. sapiens SSL Slorth 0.875804 View
ENSG00000061938 TNK2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.875309 View
ENSG00000010810 FYN ENSG00000177084 POLE H. sapiens SSL Slorth 0.875191 View
ENSG00000055130 CUL1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.875082 View
ENSG00000072518 MARK2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.874965 View
ENSG00000138069 RAB1A ENSG00000177084 POLE H. sapiens SSL Slorth 0.874376 View
ENSG00000164109 MAD2L1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.87431 View
ENSG00000170144 HNRNPA3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.873896 View
ENSG00000153147 SMARCA5 ENSG00000177084 POLE H. sapiens SSL Slorth 0.873617 View
ENSG00000136807 CDK9 ENSG00000177084 POLE H. sapiens SSL Slorth 0.873397 View
ENSG00000107404 DVL1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.872063 View
ENSG00000072062 PRKACA ENSG00000177084 POLE H. sapiens SSL Slorth 0.871931 View
ENSG00000164885 CDK5 ENSG00000177084 POLE H. sapiens SSL Slorth 0.871868 View
ENSG00000135446 CDK4 ENSG00000177084 POLE H. sapiens SSL Slorth 0.871351 View
ENSG00000135018 UBQLN1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.871129 View
ENSG00000071564 TCF3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.870913 View
ENSG00000067560 RHOA ENSG00000177084 POLE H. sapiens SSL Slorth 0.870239 View
ENSG00000113558 SKP1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.869982 View
ENSG00000129152 MYOD1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.869948 View
ENSG00000119541 VPS4B ENSG00000177084 POLE H. sapiens SSL Slorth 0.869568 View
ENSG00000172977 KAT5 ENSG00000177084 POLE H. sapiens SSL Slorth 0.869197 View
ENSG00000165280 VCP ENSG00000177084 POLE H. sapiens SSL Slorth 0.869171 View
ENSG00000094916 CBX5 ENSG00000177084 POLE H. sapiens SSL Slorth 0.868389 View
ENSG00000141027 NCOR1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.868059 View
ENSG00000108840 HDAC5 ENSG00000177084 POLE H. sapiens SSL Slorth 0.867529 View