POLE

ENSG00000177084 - H. sapiens

Pathways

Go term Description
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0051539 4 iron, 4 sulfur cluster binding

Drugs

Drug name Description
CLOFARABINE DNA inhibitor
CYTARABINE DNA polymerase (alpha/delta/epsilon) inhibitor
FLUDARABINE PHOSPHATE DNA polymerase (alpha/delta/epsilon) inhibitor
GEMCITABINE

Diseases

Disease Name
colorectal carcinoma
endometrioid carcinoma
stomach carcinoma
skin cancer
colorectal cancer susceptibility

Orthologs

Gene Organism
POL2 S. cerevisiae
pole-1 C. elegans
DNApol-epsilon255 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000112118 MCM3 ENSG00000177084 POLE H. sapiens SDL Slorth 0.928869 View
ENSG00000005007 UPF1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.928521 View
ENSG00000104738 MCM4 ENSG00000177084 POLE H. sapiens SDL Slorth 0.928244 View
ENSG00000177084 POLE ENSG00000196591 HDAC2 H. sapiens SDL Slorth 0.927328 View
ENSG00000108443 RPS6KB1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.927315 View
ENSG00000177084 POLE ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.927082 View
ENSG00000169045 HNRNPH1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.927045 View
ENSG00000149554 CHEK1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.926887 View
ENSG00000177084 POLE ENSG00000213949 ITGA1 H. sapiens SDL Slorth 0.926515 View
ENSG00000177084 POLE ENSG00000177889 UBE2N H. sapiens SSL Slorth 0.926474 View
ENSG00000177084 POLE ENSG00000186868 MAPT H. sapiens SSL Slorth 0.92628 View
ENSG00000126261 UBA2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.926171 View
ENSG00000101412 E2F1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.926126 View
ENSG00000177084 POLE ENSG00000188486 H2AFX H. sapiens SSL Slorth 0.926059 View
ENSG00000177084 POLE ENSG00000184900 SUMO3 H. sapiens SSL Slorth 0.925231 View
ENSG00000167513 CDT1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.924614 View
ENSG00000177084 POLE ENSG00000182968 SOX1 H. sapiens SDL Slorth 0.924437 View
ENSG00000061273 HDAC7 ENSG00000177084 POLE H. sapiens SSL Slorth 0.923825 View
ENSG00000177084 POLE ENSG00000188906 LRRK2 H. sapiens SSL Slorth 0.923425 View
ENSG00000169139 UBE2V2 ENSG00000177084 POLE H. sapiens SSL Slorth 0.923272 View
ENSG00000177084 POLE ENSG00000185022 MAFF H. sapiens SDL Slorth 0.922671 View
ENSG00000099956 SMARCB1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.921937 View
ENSG00000177084 POLE ENSG00000213341 CHUK H. sapiens SSL Slorth 0.921886 View
ENSG00000101868 POLA1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.921813 View
ENSG00000116016 EPAS1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.921813 View
ENSG00000112592 TBP ENSG00000177084 POLE H. sapiens SDL Slorth 0.921602 View
ENSG00000177084 POLE ENSG00000253729 PRKDC H. sapiens SSL Slorth 0.921493 View
ENSG00000177084 POLE ENSG00000183684 ALYREF H. sapiens SSL Slorth 0.921469 View
ENSG00000132646 PCNA ENSG00000177084 POLE H. sapiens SSL Slorth 0.920588 View
ENSG00000168883 USP39 ENSG00000177084 POLE H. sapiens SSL Slorth 0.920289 View
ENSG00000141646 SMAD4 ENSG00000177084 POLE H. sapiens SDL Slorth 0.919501 View
ENSG00000111276 CDKN1B ENSG00000177084 POLE H. sapiens SDL Slorth 0.919128 View
ENSG00000094916 CBX5 ENSG00000177084 POLE H. sapiens SDL Slorth 0.918478 View
ENSG00000177084 POLE ENSG00000189067 LITAF H. sapiens SDL Slorth 0.918228 View
ENSG00000177084 POLE ENSG00000186908 ZDHHC17 H. sapiens SDL Slorth 0.918146 View
ENSG00000168610 STAT3 ENSG00000177084 POLE H. sapiens SSL Slorth 0.917982 View
ENSG00000149136 SSRP1 ENSG00000177084 POLE H. sapiens SDL Slorth 0.917683 View
ENSG00000079134 THOC1 ENSG00000177084 POLE H. sapiens SSL Slorth 0.917085 View
ENSG00000070950 RAD18 ENSG00000177084 POLE H. sapiens SSL Slorth 0.916795 View
ENSG00000131759 RARA ENSG00000177084 POLE H. sapiens SDL Slorth 0.916713 View