RET

ENSG00000165731 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004872 receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005178 integrin binding

Drugs

Drug name Description
CABOZANTINIB
LENVATINIB
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
medullary thyroid
papillary thyroid
pheochromocytoma
NSCLC
Spitzoid tumour

Orthologs

No orthologs in record

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000150991 UBC ENSG00000165731 RET H. sapiens SDL Slorth 0.990539 View
ENSG00000012048 BRCA1 ENSG00000165731 RET H. sapiens SDL Slorth 0.990133 View
ENSG00000116478 HDAC1 ENSG00000165731 RET H. sapiens SDL Slorth 0.986581 View
ENSG00000091831 ESR1 ENSG00000165731 RET H. sapiens SDL Slorth 0.986563 View
ENSG00000005339 CREBBP ENSG00000165731 RET H. sapiens SDL Slorth 0.985912 View
ENSG00000100393 EP300 ENSG00000165731 RET H. sapiens SDL Slorth 0.985567 View
ENSG00000100030 MAPK1 ENSG00000165731 RET H. sapiens SDL Slorth 0.984908 View
ENSG00000141510 TP53 ENSG00000165731 RET H. sapiens SDL Slorth 0.983987 View
ENSG00000132646 PCNA ENSG00000165731 RET H. sapiens SDL Slorth 0.982778 View
ENSG00000142208 AKT1 ENSG00000165731 RET H. sapiens SDL Slorth 0.980726 View
ENSG00000080824 HSP90AA1 ENSG00000165731 RET H. sapiens SDL Slorth 0.979963 View
ENSG00000165731 RET ENSG00000189067 LITAF H. sapiens SDL Slorth 0.979516 View
ENSG00000165731 RET ENSG00000169862 CTNND2 H. sapiens SDL Slorth 0.978617 View
ENSG00000109670 FBXW7 ENSG00000165731 RET H. sapiens SSL Slorth 0.978235 View
ENSG00000133703 KRAS ENSG00000165731 RET H. sapiens SSL Slorth 0.976421 View
ENSG00000165731 RET ENSG00000186908 ZDHHC17 H. sapiens SDL Slorth 0.975923 View
ENSG00000165731 RET ENSG00000213949 ITGA1 H. sapiens SDL Slorth 0.975023 View
ENSG00000135486 HNRNPA1 ENSG00000165731 RET H. sapiens SSL Slorth 0.974088 View
ENSG00000165731 RET ENSG00000170315 UBB H. sapiens SDL Slorth 0.973944 View
ENSG00000164305 CASP3 ENSG00000165731 RET H. sapiens SSL Slorth 0.973189 View
ENSG00000101266 CSNK2A1 ENSG00000165731 RET H. sapiens SDL Slorth 0.97115 View
ENSG00000141736 ERBB2 ENSG00000165731 RET H. sapiens SSL Slorth 0.969987 View
ENSG00000132155 RAF1 ENSG00000165731 RET H. sapiens SDL Slorth 0.969932 View
ENSG00000146648 EGFR ENSG00000165731 RET H. sapiens SDL Slorth 0.969924 View
ENSG00000165731 RET ENSG00000175376 EIF1AD H. sapiens SDL Slorth 0.969674 View
ENSG00000142208 AKT1 ENSG00000165731 RET H. sapiens SSL Slorth 0.969429 View
ENSG00000165731 RET ENSG00000176720 BOK H. sapiens SDL Slorth 0.969146 View
ENSG00000164924 YWHAZ ENSG00000165731 RET H. sapiens SDL Slorth 0.968981 View
ENSG00000116030 SUMO1 ENSG00000165731 RET H. sapiens SSL Slorth 0.968912 View
ENSG00000165731 RET ENSG00000185896 LAMP1 H. sapiens SDL Slorth 0.968741 View
ENSG00000136997 MYC ENSG00000165731 RET H. sapiens SDL Slorth 0.968084 View
ENSG00000105974 CAV1 ENSG00000165731 RET H. sapiens SSL Slorth 0.96802 View
ENSG00000128245 YWHAH ENSG00000165731 RET H. sapiens SSL Slorth 0.967955 View
ENSG00000124181 PLCG1 ENSG00000165731 RET H. sapiens SSL Slorth 0.967612 View
ENSG00000101146 RAE1 ENSG00000165731 RET H. sapiens SSL Slorth 0.967365 View
ENSG00000165731 RET ENSG00000182511 FES H. sapiens SDL Slorth 0.967295 View
ENSG00000082701 GSK3B ENSG00000165731 RET H. sapiens SSL Slorth 0.966952 View
ENSG00000110395 CBL ENSG00000165731 RET H. sapiens SDL Slorth 0.966599 View
ENSG00000165731 RET ENSG00000169083 AR H. sapiens SDL Slorth 0.966408 View
ENSG00000012048 BRCA1 ENSG00000165731 RET H. sapiens SSL Slorth 0.965999 View