RET

ENSG00000165731 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004872 receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005178 integrin binding

Drugs

Drug name Description
CABOZANTINIB
LENVATINIB
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
medullary thyroid
papillary thyroid
pheochromocytoma
NSCLC
Spitzoid tumour

Orthologs

No orthologs in record

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000142192 APP ENSG00000165731 RET H. sapiens SSL Slorth 0.932094 View
ENSG00000071051 NCK2 ENSG00000165731 RET H. sapiens SSL Slorth 0.931925 View
ENSG00000145715 RASA1 ENSG00000165731 RET H. sapiens SSL Slorth 0.931786 View
ENSG00000140443 IGF1R ENSG00000165731 RET H. sapiens SSL Slorth 0.931785 View
ENSG00000165731 RET ENSG00000185591 SP1 H. sapiens SDL Slorth 0.93172 View
ENSG00000165731 RET ENSG00000204435 CSNK2B H. sapiens SDL Slorth 0.931614 View
ENSG00000165731 RET ENSG00000197299 BLM H. sapiens SSL Slorth 0.931485 View
ENSG00000102572 STK24 ENSG00000165731 RET H. sapiens SSL Slorth 0.931185 View
ENSG00000165731 RET ENSG00000175792 RUVBL1 H. sapiens SSL Slorth 0.930526 View
ENSG00000165731 RET ENSG00000185359 HGS H. sapiens SSL Slorth 0.930261 View
ENSG00000142192 APP ENSG00000165731 RET H. sapiens SDL Slorth 0.930237 View
ENSG00000157106 SMG1 ENSG00000165731 RET H. sapiens SSL Slorth 0.93006 View
ENSG00000074319 TSG101 ENSG00000165731 RET H. sapiens SSL Slorth 0.930046 View
ENSG00000096717 SIRT1 ENSG00000165731 RET H. sapiens SSL Slorth 0.930031 View
ENSG00000097007 ABL1 ENSG00000165731 RET H. sapiens SSL Slorth 0.929725 View
ENSG00000117676 RPS6KA1 ENSG00000165731 RET H. sapiens SSL Slorth 0.929599 View
ENSG00000124762 CDKN1A ENSG00000165731 RET H. sapiens SDL Slorth 0.92953 View
ENSG00000085832 EPS15 ENSG00000165731 RET H. sapiens SSL Slorth 0.929526 View
ENSG00000106799 TGFBR1 ENSG00000165731 RET H. sapiens SDL Slorth 0.929131 View
ENSG00000067560 RHOA ENSG00000165731 RET H. sapiens SSL Slorth 0.928234 View
ENSG00000136238 RAC1 ENSG00000165731 RET H. sapiens SDL Slorth 0.928125 View
ENSG00000163558 PRKCI ENSG00000165731 RET H. sapiens SSL Slorth 0.928064 View
ENSG00000150753 CCT5 ENSG00000165731 RET H. sapiens SSL Slorth 0.927379 View
ENSG00000101966 XIAP ENSG00000165731 RET H. sapiens SSL Slorth 0.927029 View
ENSG00000103275 UBE2I ENSG00000165731 RET H. sapiens SDL Slorth 0.926693 View
ENSG00000165731 RET ENSG00000198793 MTOR H. sapiens SSL Slorth 0.926572 View
ENSG00000102882 MAPK3 ENSG00000165731 RET H. sapiens SSL Slorth 0.926555 View
ENSG00000130177 CDC16 ENSG00000165731 RET H. sapiens SSL Slorth 0.926546 View
ENSG00000114062 UBE3A ENSG00000165731 RET H. sapiens SSL Slorth 0.926094 View
ENSG00000132341 RAN ENSG00000165731 RET H. sapiens SSL Slorth 0.925725 View
ENSG00000149923 PPP4C ENSG00000165731 RET H. sapiens SSL Slorth 0.925666 View
ENSG00000085733 CTTN ENSG00000165731 RET H. sapiens SDL Slorth 0.925631 View
ENSG00000051382 PIK3CB ENSG00000165731 RET H. sapiens SSL Slorth 0.925124 View
ENSG00000136628 EPRS ENSG00000165731 RET H. sapiens SSL Slorth 0.923959 View
ENSG00000165731 RET ENSG00000220205 VAMP2 H. sapiens SDL Slorth 0.923875 View
ENSG00000115904 SOS1 ENSG00000165731 RET H. sapiens SSL Slorth 0.922624 View
ENSG00000159216 RUNX1 ENSG00000165731 RET H. sapiens SDL Slorth 0.922216 View
ENSG00000113558 SKP1 ENSG00000165731 RET H. sapiens SSL Slorth 0.922194 View
ENSG00000104375 STK3 ENSG00000165731 RET H. sapiens SSL Slorth 0.922173 View
ENSG00000130699 TAF4 ENSG00000165731 RET H. sapiens SSL Slorth 0.922079 View