JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000162434 JAK1 ENSG00000133703 KRAS H. sapiens SSL BioGRID 1.0 View
ENSG00000150991 UBC ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.989523 View
ENSG00000116478 HDAC1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.989294 View
ENSG00000100393 EP300 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.988514 View
ENSG00000146648 EGFR ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.988344 View
ENSG00000091831 ESR1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.98656 View
ENSG00000005339 CREBBP ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.986053 View
ENSG00000080824 HSP90AA1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.983669 View
ENSG00000141510 TP53 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.982922 View
ENSG00000110395 CBL ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.981466 View
ENSG00000162385 MAGOH ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.980115 View
ENSG00000142208 AKT1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.979107 View
ENSG00000162434 JAK1 ENSG00000180008 SOCS4 H. sapiens SDL Slorth 0.978058 View
ENSG00000162434 JAK1 ENSG00000175376 EIF1AD H. sapiens SDL Slorth 0.97695 View
ENSG00000162434 JAK1 ENSG00000197122 SRC H. sapiens SDL Slorth 0.976277 View
ENSG00000162434 JAK1 ENSG00000205629 LCMT1 H. sapiens SDL Slorth 0.9761 View
ENSG00000162434 JAK1 ENSG00000169047 IRS1 H. sapiens SDL Slorth 0.974865 View
ENSG00000162434 JAK1 ENSG00000171150 SOCS5 H. sapiens SDL Slorth 0.974715 View
ENSG00000162434 JAK1 ENSG00000213949 ITGA1 H. sapiens SDL Slorth 0.974613 View
ENSG00000072736 NFATC3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.973929 View
ENSG00000110048 OSBP ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.973878 View
ENSG00000162434 JAK1 ENSG00000182968 SOX1 H. sapiens SDL Slorth 0.973851 View
ENSG00000162434 JAK1 ENSG00000164736 SOX17 H. sapiens SDL Slorth 0.973851 View
ENSG00000162434 JAK1 ENSG00000185896 LAMP1 H. sapiens SDL Slorth 0.973642 View
ENSG00000134086 VHL ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.973597 View
ENSG00000149554 CHEK1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.973539 View
ENSG00000096717 SIRT1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.973333 View
ENSG00000162434 JAK1 ENSG00000162889 MAPKAPK2 H. sapiens SDL Slorth 0.972712 View
ENSG00000110031 LPXN ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.972451 View
ENSG00000135446 CDK4 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.971091 View
ENSG00000162434 JAK1 ENSG00000184937 WT1 H. sapiens SDL Slorth 0.971063 View
ENSG00000162434 JAK1 ENSG00000169926 KLF13 H. sapiens SDL Slorth 0.97042 View
ENSG00000129245 FXR2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.970408 View
ENSG00000154997 SEPT14 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.970408 View
ENSG00000088367 EPB41L1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.970116 View
ENSG00000162434 JAK1 ENSG00000206181 TCEB3B H. sapiens SDL Slorth 0.969873 View
ENSG00000162434 JAK1 ENSG00000163098 BIRC8 H. sapiens SDL Slorth 0.96987 View
ENSG00000162434 JAK1 ENSG00000185697 MYBL1 H. sapiens SDL Slorth 0.969772 View
ENSG00000077380 DYNC1I2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.96968 View
ENSG00000162434 JAK1 ENSG00000189067 LITAF H. sapiens SDL Slorth 0.969436 View