JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000128271 ADORA2A ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950613 View
ENSG00000162434 JAK1 ENSG00000177885 GRB2 H. sapiens SDL Slorth 0.950579 View
ENSG00000135312 HTR1B ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950557 View
ENSG00000100030 MAPK1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950508 View
ENSG00000134138 MEIS2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950488 View
ENSG00000072062 PRKACA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.950433 View
ENSG00000145734 BDP1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.9504 View
ENSG00000162434 JAK1 ENSG00000185651 UBE2L3 H. sapiens SSL Slorth 0.950358 View
ENSG00000071564 TCF3 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.950265 View
ENSG00000092421 SEMA6A ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950248 View
ENSG00000162434 JAK1 ENSG00000175793 SFN H. sapiens SSL Slorth 0.950211 View
ENSG00000151150 ANK3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950114 View
ENSG00000143355 LHX9 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950114 View
ENSG00000115507 OTX1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950114 View
ENSG00000048540 LMO3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950114 View
ENSG00000162434 JAK1 ENSG00000163932 PRKCD H. sapiens SSL Slorth 0.950082 View
ENSG00000105173 CCNE1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.94996 View
ENSG00000004848 ARX ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949943 View
ENSG00000137166 FOXP4 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949931 View
ENSG00000114861 FOXP1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949931 View
ENSG00000061918 GUCY1B3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949931 View
ENSG00000143257 NR1I3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949851 View
ENSG00000135597 REPS1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949825 View
ENSG00000079337 RAPGEF3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949789 View
ENSG00000105568 PPP2R1A ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.949692 View
ENSG00000085511 MAP3K4 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.949684 View
ENSG00000162434 JAK1 ENSG00000182866 LCK H. sapiens SSL Slorth 0.949681 View
ENSG00000132669 RIN2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949595 View
ENSG00000149136 SSRP1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.949363 View
ENSG00000117625 RCOR3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949346 View
ENSG00000124762 CDKN1A ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.949304 View
ENSG00000136754 ABI1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.94928 View
ENSG00000110148 CCKBR ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949031 View
ENSG00000125656 CLPP ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949031 View
ENSG00000079134 THOC1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.949022 View
ENSG00000090889 KIF4A ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.949008 View
ENSG00000132170 PPARG ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.948959 View
ENSG00000146232 NFKBIE ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.948932 View
ENSG00000096968 JAK2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.948928 View
ENSG00000162434 JAK1 ENSG00000177606 JUN H. sapiens SSL Slorth 0.948919 View