JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000134982 APC ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.954969 View
ENSG00000108443 RPS6KB1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.954943 View
ENSG00000065559 MAP2K4 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.95479 View
ENSG00000162434 JAK1 ENSG00000169047 IRS1 H. sapiens SSL Slorth 0.954788 View
ENSG00000073111 MCM2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.954564 View
ENSG00000105810 CDK6 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.954554 View
ENSG00000109670 FBXW7 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.954533 View
ENSG00000134308 YWHAQ ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.954497 View
ENSG00000085832 EPS15 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.954496 View
ENSG00000162434 JAK1 ENSG00000169045 HNRNPH1 H. sapiens SSL Slorth 0.954479 View
ENSG00000148908 RGS10 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.954467 View
ENSG00000162434 JAK1 ENSG00000183735 TBK1 H. sapiens SSL Slorth 0.954334 View
ENSG00000104129 DNAJC17 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.954274 View
ENSG00000137673 MMP7 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.954209 View
ENSG00000106346 USP42 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.954167 View
ENSG00000111875 ASF1A ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.954166 View
ENSG00000109971 HSPA8 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.954095 View
ENSG00000162434 JAK1 ENSG00000196591 HDAC2 H. sapiens SSL Slorth 0.953969 View
ENSG00000162434 JAK1 ENSG00000172531 PPP1CA H. sapiens SSL Slorth 0.953953 View
ENSG00000008196 TFAP2B ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.953942 View
ENSG00000055332 EIF2AK2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.953879 View
ENSG00000108424 KPNB1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.953869 View
ENSG00000133101 CCNA1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.953728 View
ENSG00000128908 INO80 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.953669 View
ENSG00000109320 NFKB1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.953616 View
ENSG00000146648 EGFR ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.953548 View
ENSG00000162434 JAK1 ENSG00000196470 SIAH1 H. sapiens SSL Slorth 0.953483 View
ENSG00000125967 NECAB3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.95344 View
ENSG00000117707 PROX1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.95344 View
ENSG00000147010 SH3KBP1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.953415 View
ENSG00000094804 CDC6 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.953382 View
ENSG00000162434 JAK1 ENSG00000181163 NPM1 H. sapiens SSL Slorth 0.953295 View
ENSG00000162434 JAK1 ENSG00000283094 PTEN H. sapiens SSL Slorth 0.953288 View
ENSG00000132341 RAN ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.953141 View
ENSG00000137825 ITPKA ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.953123 View
ENSG00000162434 JAK1 ENSG00000166501 PRKCB H. sapiens SSL Slorth 0.953003 View
ENSG00000115325 DOK1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.952935 View
ENSG00000162434 JAK1 ENSG00000169372 CRADD H. sapiens SDL Slorth 0.95292 View
ENSG00000135723 FHOD1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.952894 View
ENSG00000114062 UBE3A ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.952885 View