JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000134057 CCNB1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.961934 View
ENSG00000141646 SMAD4 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.961923 View
ENSG00000130561 SAG ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961887 View
ENSG00000124486 USP9X ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.961871 View
ENSG00000145386 CCNA2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.961806 View
ENSG00000079335 CDC14A ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.96179 View
ENSG00000012048 BRCA1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961754 View
ENSG00000139219 COL2A1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961733 View
ENSG00000162434 JAK1 ENSG00000196923 PDLIM7 H. sapiens SDL Slorth 0.961682 View
ENSG00000110330 BIRC2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.961588 View
ENSG00000099785 MARCH2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961258 View
ENSG00000148248 SURF4 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961258 View
ENSG00000135604 STX11 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961231 View
ENSG00000130703 OSBPL2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961231 View
ENSG00000149968 MMP3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961211 View
ENSG00000102996 MMP15 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961211 View
ENSG00000067829 IDH3G ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961211 View
ENSG00000100372 SLC25A17 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961205 View
ENSG00000111218 PRMT8 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961156 View
ENSG00000162434 JAK1 ENSG00000184675 AMER1 H. sapiens SDL Slorth 0.961136 View
ENSG00000141503 MINK1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.961124 View
ENSG00000103194 USP10 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.961119 View
ENSG00000141480 ARRB2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.960805 View
ENSG00000162434 JAK1 ENSG00000244405 ETV5 H. sapiens SDL Slorth 0.960629 View
ENSG00000148677 ANKRD1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.960561 View
ENSG00000142751 GPN2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.960556 View
ENSG00000142208 AKT1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.960462 View
ENSG00000162434 JAK1 ENSG00000198838 RYR3 H. sapiens SDL Slorth 0.960443 View
ENSG00000121774 KHDRBS1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.960425 View
ENSG00000101365 IDH3B ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.960401 View
ENSG00000162434 JAK1 ENSG00000163932 PRKCD H. sapiens SDL Slorth 0.960387 View
ENSG00000101868 POLA1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.960382 View
ENSG00000135341 MAP3K7 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.960336 View
ENSG00000113721 PDGFRB ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.960314 View
ENSG00000162434 JAK1 ENSG00000184900 SUMO3 H. sapiens SSL Slorth 0.96031 View
ENSG00000105290 APLP1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.960294 View
ENSG00000134853 PDGFRA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.960136 View
ENSG00000162434 JAK1 ENSG00000169756 LIMS1 H. sapiens SDL Slorth 0.96012 View
ENSG00000148400 NOTCH1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.960072 View
ENSG00000102882 MAPK3 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.960037 View