JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000162434 JAK1 ENSG00000165671 NSD1 H. sapiens SDL Slorth 0.959884 View
ENSG00000082898 XPO1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.959873 View
ENSG00000160193 WDR4 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.959767 View
ENSG00000162434 JAK1 ENSG00000166851 PLK1 H. sapiens SSL Slorth 0.959373 View
ENSG00000097007 ABL1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.959207 View
ENSG00000108953 YWHAE ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.959194 View
ENSG00000005007 UPF1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.95893 View
ENSG00000162434 JAK1 ENSG00000175766 EIF4E1B H. sapiens SDL Slorth 0.958862 View
ENSG00000103275 UBE2I ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.958829 View
ENSG00000162434 JAK1 ENSG00000184470 TXNRD2 H. sapiens SDL Slorth 0.95878 View
ENSG00000001626 CFTR ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.95875 View
ENSG00000101146 RAE1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.958574 View
ENSG00000153922 CHD1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.958565 View
ENSG00000138376 BARD1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.958543 View
ENSG00000102317 RBM3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.958493 View
ENSG00000162434 JAK1 ENSG00000164056 SPRY1 H. sapiens SDL Slorth 0.95828 View
ENSG00000162434 JAK1 ENSG00000185359 HGS H. sapiens SSL Slorth 0.958116 View
ENSG00000127511 SIN3B ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.958038 View
ENSG00000162434 JAK1 ENSG00000178188 SH2B1 H. sapiens SDL Slorth 0.958012 View
ENSG00000005339 CREBBP ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.957964 View
ENSG00000128245 YWHAH ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.957962 View
ENSG00000118046 STK11 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.957952 View
ENSG00000162434 JAK1 ENSG00000169714 CNBP H. sapiens SDL Slorth 0.957892 View
ENSG00000109906 ZBTB16 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.957781 View
ENSG00000150093 ITGB1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.957664 View
ENSG00000004897 CDC27 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.957654 View
ENSG00000162434 JAK1 ENSG00000183207 RUVBL2 H. sapiens SSL Slorth 0.957649 View
ENSG00000132466 ANKRD17 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.957612 View
ENSG00000120539 MASTL ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.957474 View
ENSG00000162434 JAK1 ENSG00000254087 LYN H. sapiens SSL Slorth 0.957323 View
ENSG00000155465 SLC7A7 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.957254 View
ENSG00000100982 PCIF1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.957254 View
ENSG00000162434 JAK1 ENSG00000197299 BLM H. sapiens SSL Slorth 0.957182 View
ENSG00000136237 RAPGEF5 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.957166 View
ENSG00000162434 JAK1 ENSG00000172071 EIF2AK3 H. sapiens SDL Slorth 0.957157 View
ENSG00000162434 JAK1 ENSG00000165506 DNAAF2 H. sapiens SDL Slorth 0.957132 View
ENSG00000070950 RAD18 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.957116 View
ENSG00000086619 ERO1B ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.957052 View
ENSG00000153944 MSI2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.95705 View
ENSG00000124782 RREB1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.95695 View