JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000154229 PRKCA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.952821 View
ENSG00000162434 JAK1 ENSG00000165416 SUGT1 H. sapiens SSL Slorth 0.9528 View
ENSG00000016082 ISL1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.952732 View
ENSG00000096968 JAK2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.952646 View
ENSG00000100852 ARHGAP5 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.952645 View
ENSG00000159352 PSMD4 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.952565 View
ENSG00000152601 MBNL1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.952546 View
ENSG00000139668 WDFY2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.952534 View
ENSG00000115221 ITGB6 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.952526 View
ENSG00000049323 LTBP1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.952498 View
ENSG00000104365 IKBKB ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.952399 View
ENSG00000007264 MATK ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.952333 View
ENSG00000117676 RPS6KA1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.952331 View
ENSG00000162434 JAK1 ENSG00000187555 USP7 H. sapiens SSL Slorth 0.952329 View
ENSG00000062822 POLD1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.952259 View
ENSG00000091831 ESR1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.952141 View
ENSG00000129559 NEDD8 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.951971 View
ENSG00000162434 JAK1 ENSG00000167986 DDB1 H. sapiens SSL Slorth 0.951907 View
ENSG00000145358 DDIT4L ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.951885 View
ENSG00000110092 CCND1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.951791 View
ENSG00000100030 MAPK1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.951683 View
ENSG00000162434 JAK1 ENSG00000198793 MTOR H. sapiens SSL Slorth 0.951505 View
ENSG00000162434 JAK1 ENSG00000188906 LRRK2 H. sapiens SSL Slorth 0.951447 View
ENSG00000084676 NCOA1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.951302 View
ENSG00000143033 MTF2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.951218 View
ENSG00000099817 POLR2E ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.951101 View
ENSG00000111262 KCNA1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.951014 View
ENSG00000111049 MYF5 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950889 View
ENSG00000118900 UBN1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950859 View
ENSG00000102145 GATA1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950859 View
ENSG00000072315 TRPC5 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950859 View
ENSG00000139998 RAB15 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950859 View
ENSG00000066923 STAG3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950811 View
ENSG00000162434 JAK1 ENSG00000168610 STAT3 H. sapiens SSL Slorth 0.950703 View
ENSG00000162434 JAK1 ENSG00000167513 CDT1 H. sapiens SSL Slorth 0.950696 View
ENSG00000072401 UBE2D1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.950671 View
ENSG00000060069 CTDP1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.950651 View
ENSG00000125810 CD93 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950613 View
ENSG00000041353 RAB27B ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950613 View
ENSG00000128271 ADORA2A ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.950613 View