JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000145604 SKP2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.94393 View
ENSG00000101132 PFDN4 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.943873 View
ENSG00000126785 RHOJ ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.943772 View
ENSG00000082146 STRADB ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.943766 View
ENSG00000109320 NFKB1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.943737 View
ENSG00000124164 VAPB ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.943736 View
ENSG00000162434 JAK1 ENSG00000178568 ERBB4 H. sapiens SSL Slorth 0.943662 View
ENSG00000106290 TAF6 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.943513 View
ENSG00000111540 RAB5B ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.943425 View
ENSG00000162434 JAK1 ENSG00000172534 HCFC1 H. sapiens SSL Slorth 0.943349 View
ENSG00000087995 METTL2A ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.943325 View
ENSG00000145506 NKD2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.943155 View
ENSG00000075340 ADD2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.943147 View
ENSG00000041982 TNC ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.943135 View
ENSG00000112531 QKI ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.943131 View
ENSG00000113456 RAD1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.943062 View
ENSG00000162434 JAK1 ENSG00000164885 CDK5 H. sapiens SSL Slorth 0.943051 View
ENSG00000162434 JAK1 ENSG00000168453 HR H. sapiens SDL Slorth 0.942995 View
ENSG00000135776 ABCB10 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.94294 View
ENSG00000108840 HDAC5 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.942915 View
ENSG00000099804 CDC34 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.942667 View
ENSG00000044574 HSPA5 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.942656 View
ENSG00000162434 JAK1 ENSG00000198742 SMURF1 H. sapiens SSL Slorth 0.942534 View
ENSG00000063660 GPC1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.94253 View
ENSG00000108830 RND2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.942406 View
ENSG00000102978 POLR2C ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.942312 View
ENSG00000135624 CCT7 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.942286 View
ENSG00000064012 CASP8 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.942276 View
ENSG00000162434 JAK1 ENSG00000204390 HSPA1L H. sapiens SDL Slorth 0.94224 View
ENSG00000116990 MYCL ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.942232 View
ENSG00000145331 TRMT10A ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.942185 View
ENSG00000148840 PPRC1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.942185 View
ENSG00000132383 RPA1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.942139 View
ENSG00000162434 JAK1 ENSG00000182872 RBM10 H. sapiens SDL Slorth 0.94193 View
ENSG00000123094 RASSF8 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.941913 View
ENSG00000099365 STX1B ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.94186 View
ENSG00000162434 JAK1 ENSG00000169696 ASPSCR1 H. sapiens SDL Slorth 0.941814 View
ENSG00000125952 MAX ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.941764 View
ENSG00000108773 KAT2A ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.941704 View
ENSG00000162434 JAK1 ENSG00000187522 HSPA14 H. sapiens SDL Slorth 0.941682 View