JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000162434 JAK1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.936425 View
ENSG00000124232 RBPJL ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.936343 View
ENSG00000162434 JAK1 ENSG00000172977 KAT5 H. sapiens SSL Slorth 0.936324 View
ENSG00000122966 CIT ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.936207 View
ENSG00000149311 ATM ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.93614 View
ENSG00000143420 ENSA ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.93605 View
ENSG00000006451 RALA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.936005 View
ENSG00000113558 SKP1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.935885 View
ENSG00000136936 XPA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.935872 View
ENSG00000132646 PCNA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.935783 View
ENSG00000122592 HOXA7 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.935771 View
ENSG00000130751 NPAS1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.935771 View
ENSG00000063438 AHRR ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.935771 View
ENSG00000151322 NPAS3 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.935771 View
ENSG00000106689 LHX2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.935771 View
ENSG00000162434 JAK1 ENSG00000181788 SIAH2 H. sapiens SDL Slorth 0.935669 View
ENSG00000159496 RGL4 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.935583 View
ENSG00000162434 JAK1 ENSG00000198793 MTOR H. sapiens SDL Slorth 0.935582 View
ENSG00000140750 ARHGAP17 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.935559 View
ENSG00000119729 RHOQ ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.935511 View
ENSG00000128512 DOCK4 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.935349 View
ENSG00000125084 WNT1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.934958 View
ENSG00000113558 SKP1 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.93494 View
ENSG00000061938 TNK2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.93489 View
ENSG00000162434 JAK1 ENSG00000163558 PRKCI H. sapiens SDL Slorth 0.934808 View
ENSG00000162434 JAK1 ENSG00000169967 MAP3K2 H. sapiens SSL Slorth 0.934765 View
ENSG00000005882 PDK2 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.934743 View
ENSG00000144554 FANCD2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.934499 View
ENSG00000136518 ACTL6A ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.934481 View
ENSG00000162434 JAK1 ENSG00000169083 AR H. sapiens SSL Slorth 0.934477 View
ENSG00000162434 JAK1 ENSG00000165806 CASP7 H. sapiens SDL Slorth 0.934432 View
ENSG00000162434 JAK1 ENSG00000166508 MCM7 H. sapiens SSL Slorth 0.934348 View
ENSG00000101460 MAP1LC3A ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.934272 View
ENSG00000010017 RANBP9 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.93413 View
ENSG00000112319 EYA4 ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.933993 View
ENSG00000156970 BUB1B ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.933922 View
ENSG00000072803 FBXW11 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.933909 View
ENSG00000162434 JAK1 ENSG00000175792 RUVBL1 H. sapiens SSL Slorth 0.933908 View
ENSG00000058404 CAMK2B ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.933894 View
ENSG00000162434 JAK1 ENSG00000170248 PDCD6IP H. sapiens SDL Slorth 0.933839 View