ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000129245 FXR2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.962896 View
ENSG00000141736 ERBB2 ENSG00000157540 DYRK1A H. sapiens SDL Slorth 0.962874 View
ENSG00000141736 ERBB2 ENSG00000169252 ADRB2 H. sapiens SDL Slorth 0.962852 View
ENSG00000141736 ERBB2 ENSG00000164885 CDK5 H. sapiens SSL Slorth 0.962775 View
ENSG00000101665 SMAD7 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.962689 View
ENSG00000141736 ERBB2 ENSG00000184470 TXNRD2 H. sapiens SDL Slorth 0.962673 View
ENSG00000087586 AURKA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.96266 View
ENSG00000113721 PDGFRB ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.962652 View
ENSG00000121879 PIK3CA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.962624 View
ENSG00000141736 ERBB2 ENSG00000169891 REPS2 H. sapiens SDL Slorth 0.962385 View
ENSG00000141736 ERBB2 ENSG00000187555 USP7 H. sapiens SSL Slorth 0.962223 View
ENSG00000077279 DCX ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.962223 View
ENSG00000001626 CFTR ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.962167 View
ENSG00000130726 TRIM28 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.962116 View
ENSG00000128908 INO80 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.9621 View
ENSG00000078747 ITCH ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.962064 View
ENSG00000141736 ERBB2 ENSG00000154447 SH3RF1 H. sapiens SDL Slorth 0.962059 View
ENSG00000137073 UBAP2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.961894 View
ENSG00000141736 ERBB2 ENSG00000163098 BIRC8 H. sapiens SDL Slorth 0.961833 View
ENSG00000141736 ERBB2 ENSG00000173039 RELA H. sapiens SSL Slorth 0.961755 View
ENSG00000085511 MAP3K4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.961732 View
ENSG00000141736 ERBB2 ENSG00000172534 HCFC1 H. sapiens SSL Slorth 0.961723 View
ENSG00000141736 ERBB2 ENSG00000150753 CCT5 H. sapiens SSL Slorth 0.961712 View
ENSG00000141736 ERBB2 ENSG00000142453 CARM1 H. sapiens SSL Slorth 0.961669 View
ENSG00000078403 MLLT10 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.961518 View
ENSG00000141736 ERBB2 ENSG00000168148 HIST3H3 H. sapiens SSL Slorth 0.961511 View
ENSG00000141736 ERBB2 ENSG00000154767 XPC H. sapiens SDL Slorth 0.961401 View
ENSG00000101412 E2F1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.961311 View
ENSG00000141736 ERBB2 ENSG00000168036 CTNNB1 H. sapiens SDL Slorth 0.961278 View
ENSG00000096968 JAK2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.961213 View
ENSG00000141736 ERBB2 ENSG00000254772 EEF1G H. sapiens SSL Slorth 0.961208 View
ENSG00000124762 CDKN1A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.9612 View
ENSG00000141736 ERBB2 ENSG00000245848 CEBPA H. sapiens SSL Slorth 0.961103 View
ENSG00000141736 ERBB2 ENSG00000188130 MAPK12 H. sapiens SDL Slorth 0.9611 View
ENSG00000141736 ERBB2 ENSG00000166598 HSP90B1 H. sapiens SSL Slorth 0.96108 View
ENSG00000137942 FNBP1L ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.961076 View
ENSG00000141736 ERBB2 ENSG00000186868 MAPT H. sapiens SSL Slorth 0.961076 View
ENSG00000141736 ERBB2 ENSG00000213341 CHUK H. sapiens SSL Slorth 0.961039 View
ENSG00000141736 ERBB2 ENSG00000166508 MCM7 H. sapiens SSL Slorth 0.96099 View
ENSG00000141736 ERBB2 ENSG00000157514 TSC22D3 H. sapiens SDL Slorth 0.960883 View