ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000124181 PLCG1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.973492 View
ENSG00000141736 ERBB2 ENSG00000148516 ZEB1 H. sapiens SDL Slorth 0.973474 View
ENSG00000141736 ERBB2 ENSG00000185345 PARK2 H. sapiens SSL Slorth 0.973468 View
ENSG00000141736 ERBB2 ENSG00000171791 BCL2 H. sapiens SSL Slorth 0.973407 View
ENSG00000132155 RAF1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.973372 View
ENSG00000141736 ERBB2 ENSG00000198353 HOXC4 H. sapiens SDL Slorth 0.973262 View
ENSG00000005339 CREBBP ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.973251 View
ENSG00000141736 ERBB2 ENSG00000159692 CTBP1 H. sapiens SSL Slorth 0.973074 View
ENSG00000141736 ERBB2 ENSG00000198087 CD2AP H. sapiens SDL Slorth 0.972975 View
ENSG00000132155 RAF1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.97294 View
ENSG00000069869 NEDD4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.972936 View
ENSG00000139687 RB1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.972879 View
ENSG00000141736 ERBB2 ENSG00000157168 NRG1 H. sapiens SDL Slorth 0.972837 View
ENSG00000141736 ERBB2 ENSG00000166851 PLK1 H. sapiens SSL Slorth 0.972772 View
ENSG00000101266 CSNK2A1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.972708 View
ENSG00000141736 ERBB2 ENSG00000168646 AXIN2 H. sapiens SDL Slorth 0.972623 View
ENSG00000141736 ERBB2 ENSG00000198793 MTOR H. sapiens SSL Slorth 0.972422 View
ENSG00000141736 ERBB2 ENSG00000169926 KLF13 H. sapiens SDL Slorth 0.97241 View
ENSG00000141736 ERBB2 ENSG00000206181 TCEB3B H. sapiens SDL Slorth 0.972348 View
ENSG00000141736 ERBB2 ENSG00000167552 TUBA1A H. sapiens SSL Slorth 0.972311 View
ENSG00000141736 ERBB2 ENSG00000169862 CTNND2 H. sapiens SDL Slorth 0.972307 View
ENSG00000141736 ERBB2 ENSG00000254087 LYN H. sapiens SSL Slorth 0.972306 View
ENSG00000130939 UBE4B ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.971963 View
ENSG00000141736 ERBB2 ENSG00000185651 UBE2L3 H. sapiens SSL Slorth 0.971939 View
ENSG00000141736 ERBB2 ENSG00000157404 KIT H. sapiens SSL Slorth 0.971895 View
ENSG00000141736 ERBB2 ENSG00000169139 UBE2V2 H. sapiens SSL Slorth 0.971886 View
ENSG00000141736 ERBB2 ENSG00000154229 PRKCA H. sapiens SSL Slorth 0.971645 View
ENSG00000134057 CCNB1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.971623 View
ENSG00000141736 ERBB2 ENSG00000141738 GRB7 H. sapiens SDL Slorth 0.971428 View
ENSG00000116030 SUMO1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.971389 View
ENSG00000141736 ERBB2 ENSG00000155090 KLF10 H. sapiens SDL Slorth 0.971357 View
ENSG00000103275 UBE2I ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.971315 View
ENSG00000117399 CDC20 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.97119 View
ENSG00000097007 ABL1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.971152 View
ENSG00000141736 ERBB2 ENSG00000198561 CTNND1 H. sapiens SSL Slorth 0.971006 View
ENSG00000141736 ERBB2 ENSG00000165115 KIF27 H. sapiens SDL Slorth 0.970818 View
ENSG00000110048 OSBP ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.970728 View
ENSG00000141736 ERBB2 ENSG00000144668 ITGA9 H. sapiens SDL Slorth 0.970705 View
ENSG00000101868 POLA1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.970695 View
ENSG00000103194 USP10 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.970659 View