ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141736 ERBB2 ENSG00000167513 CDT1 H. sapiens SSL Slorth 0.965348 View
ENSG00000108443 RPS6KB1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.965294 View
ENSG00000109971 HSPA8 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.965264 View
ENSG00000141736 ERBB2 ENSG00000143556 S100A7 H. sapiens SDL Slorth 0.965086 View
ENSG00000141736 ERBB2 ENSG00000186575 NF2 H. sapiens SSL Slorth 0.965047 View
ENSG00000141736 ERBB2 ENSG00000170312 CDK1 H. sapiens SSL Slorth 0.965039 View
ENSG00000104140 RHOV ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.965039 View
ENSG00000100320 RBFOX2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.965034 View
ENSG00000141736 ERBB2 ENSG00000196218 RYR1 H. sapiens SDL Slorth 0.964936 View
ENSG00000141736 ERBB2 ENSG00000205629 LCMT1 H. sapiens SDL Slorth 0.964902 View
ENSG00000141736 ERBB2 ENSG00000154229 PRKCA H. sapiens SDL Slorth 0.964893 View
ENSG00000141736 ERBB2 ENSG00000172071 EIF2AK3 H. sapiens SDL Slorth 0.964873 View
ENSG00000134086 VHL ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.964865 View
ENSG00000141736 ERBB2 ENSG00000149311 ATM H. sapiens SSL Slorth 0.964851 View
ENSG00000121022 COPS5 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.964823 View
ENSG00000109332 UBE2D3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.964789 View
ENSG00000109971 HSPA8 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.964765 View
ENSG00000112118 MCM3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.964715 View
ENSG00000141736 ERBB2 ENSG00000173404 INSM1 H. sapiens SDL Slorth 0.964637 View
ENSG00000062822 POLD1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.964539 View
ENSG00000141480 ARRB2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.964357 View
ENSG00000061273 HDAC7 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.964211 View
ENSG00000141736 ERBB2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.964185 View
ENSG00000141736 ERBB2 ENSG00000143799 PARP1 H. sapiens SSL Slorth 0.964059 View
ENSG00000141736 ERBB2 ENSG00000165392 WRN H. sapiens SSL Slorth 0.964003 View
ENSG00000134982 APC ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.963919 View
ENSG00000141736 ERBB2 ENSG00000144028 SNRNP200 H. sapiens SSL Slorth 0.963894 View
ENSG00000078140 UBE2K ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.963711 View
ENSG00000141736 ERBB2 ENSG00000145632 PLK2 H. sapiens SDL Slorth 0.963686 View
ENSG00000141736 ERBB2 ENSG00000164362 TERT H. sapiens SSL Slorth 0.963681 View
ENSG00000141736 ERBB2 ENSG00000148400 NOTCH1 H. sapiens SSL Slorth 0.963647 View
ENSG00000110031 LPXN ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.963506 View
ENSG00000141736 ERBB2 ENSG00000198838 RYR3 H. sapiens SDL Slorth 0.963447 View
ENSG00000141736 ERBB2 ENSG00000171150 SOCS5 H. sapiens SDL Slorth 0.963343 View
ENSG00000136518 ACTL6A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.963301 View
ENSG00000117676 RPS6KA1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.963019 View
ENSG00000141736 ERBB2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.962989 View
ENSG00000111049 MYF5 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.96297 View
ENSG00000100030 MAPK1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.962932 View
ENSG00000141736 ERBB2 ENSG00000188486 H2AFX H. sapiens SSL Slorth 0.962903 View