ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141027 NCOR1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.959288 View
ENSG00000141736 ERBB2 ENSG00000166226 CCT2 H. sapiens SSL Slorth 0.959236 View
ENSG00000141736 ERBB2 ENSG00000154767 XPC H. sapiens SSL Slorth 0.959205 View
ENSG00000110395 CBL ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.959026 View
ENSG00000088367 EPB41L1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.95902 View
ENSG00000141736 ERBB2 ENSG00000170248 PDCD6IP H. sapiens SSL Slorth 0.958833 View
ENSG00000141736 ERBB2 ENSG00000166949 SMAD3 H. sapiens SSL Slorth 0.95878 View
ENSG00000139687 RB1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.958768 View
ENSG00000141736 ERBB2 ENSG00000151422 FER H. sapiens SDL Slorth 0.958687 View
ENSG00000141736 ERBB2 ENSG00000169083 AR H. sapiens SDL Slorth 0.958647 View
ENSG00000072163 LIMS2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.958639 View
ENSG00000105810 CDK6 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.958576 View
ENSG00000141736 ERBB2 ENSG00000166200 COPS2 H. sapiens SSL Slorth 0.958537 View
ENSG00000141736 ERBB2 ENSG00000198087 CD2AP H. sapiens SSL Slorth 0.958519 View
ENSG00000141736 ERBB2 ENSG00000170315 UBB H. sapiens SDL Slorth 0.95851 View
ENSG00000141736 ERBB2 ENSG00000185896 LAMP1 H. sapiens SDL Slorth 0.958466 View
ENSG00000141736 ERBB2 ENSG00000205531 NAP1L4 H. sapiens SSL Slorth 0.958418 View
ENSG00000141736 ERBB2 ENSG00000178568 ERBB4 H. sapiens SSL Slorth 0.958273 View
ENSG00000064012 CASP8 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.958264 View
ENSG00000141736 ERBB2 ENSG00000170035 UBE2E3 H. sapiens SSL Slorth 0.958255 View
ENSG00000141736 ERBB2 ENSG00000183791 TCEB3C H. sapiens SDL Slorth 0.958222 View
ENSG00000023445 BIRC3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.958211 View
ENSG00000141736 ERBB2 ENSG00000169439 SDC2 H. sapiens SSL Slorth 0.95819 View
ENSG00000089159 PXN ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.958177 View
ENSG00000141736 ERBB2 ENSG00000164305 CASP3 H. sapiens SSL Slorth 0.958134 View
ENSG00000141736 ERBB2 ENSG00000152284 TCF7L1 H. sapiens SDL Slorth 0.958042 View
ENSG00000132466 ANKRD17 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.958042 View
ENSG00000141736 ERBB2 ENSG00000165506 DNAAF2 H. sapiens SDL Slorth 0.958013 View
ENSG00000141736 ERBB2 ENSG00000177981 ASB8 H. sapiens SDL Slorth 0.957875 View
ENSG00000141736 ERBB2 ENSG00000178394 HTR1A H. sapiens SDL Slorth 0.957734 View
ENSG00000082146 STRADB ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.957711 View
ENSG00000114423 CBLB ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.957686 View
ENSG00000141736 ERBB2 ENSG00000185359 HGS H. sapiens SSL Slorth 0.957561 View
ENSG00000113558 SKP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.957545 View
ENSG00000141736 ERBB2 ENSG00000186908 ZDHHC17 H. sapiens SDL Slorth 0.957531 View
ENSG00000141736 ERBB2 ENSG00000158987 RAPGEF6 H. sapiens SDL Slorth 0.957401 View
ENSG00000141736 ERBB2 ENSG00000141968 VAV1 H. sapiens SSL Slorth 0.957391 View
ENSG00000141736 ERBB2 ENSG00000178573 MAF H. sapiens SDL Slorth 0.957256 View
ENSG00000141736 ERBB2 ENSG00000163932 PRKCD H. sapiens SDL Slorth 0.95721 View
ENSG00000093009 CDC45 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.957207 View