ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141736 ERBB2 ENSG00000171824 EXOSC10 H. sapiens SSL Slorth 0.952334 View
ENSG00000067829 IDH3G ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.952203 View
ENSG00000060069 CTDP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.952178 View
ENSG00000141736 ERBB2 ENSG00000147133 TAF1 H. sapiens SSL Slorth 0.952137 View
ENSG00000086619 ERO1B ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.952131 View
ENSG00000130703 OSBPL2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.952106 View
ENSG00000100372 SLC25A17 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.952074 View
ENSG00000123600 METTL8 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.951846 View
ENSG00000141736 ERBB2 ENSG00000170315 UBB H. sapiens SSL Slorth 0.951746 View
ENSG00000141736 ERBB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.951696 View
ENSG00000130766 SESN2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.951621 View
ENSG00000141736 ERBB2 ENSG00000196628 TCF4 H. sapiens SSL Slorth 0.951581 View
ENSG00000103197 TSC2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.95152 View
ENSG00000111218 PRMT8 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.951396 View
ENSG00000141736 ERBB2 ENSG00000146094 DOK3 H. sapiens SDL Slorth 0.951302 View
ENSG00000141736 ERBB2 ENSG00000160224 AIRE H. sapiens SDL Slorth 0.95121 View
ENSG00000141736 ERBB2 ENSG00000172936 MYD88 H. sapiens SSL Slorth 0.95118 View
ENSG00000141736 ERBB2 ENSG00000169372 CRADD H. sapiens SDL Slorth 0.951057 View
ENSG00000099804 CDC34 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.951044 View
ENSG00000141736 ERBB2 ENSG00000168439 STIP1 H. sapiens SSL Slorth 0.950962 View
ENSG00000079432 CIC ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.950926 View
ENSG00000114554 PLXNA1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.950905 View
ENSG00000074319 TSG101 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.950893 View
ENSG00000132849 PATJ ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.950746 View
ENSG00000101266 CSNK2A1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.950743 View
ENSG00000127586 CHTF18 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.950714 View
ENSG00000106462 EZH2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.950624 View
ENSG00000141736 ERBB2 ENSG00000155846 PPARGC1B H. sapiens SDL Slorth 0.950608 View
ENSG00000007908 SELE ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.950568 View
ENSG00000085449 WDFY1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.950525 View
ENSG00000141736 ERBB2 ENSG00000165025 SYK H. sapiens SDL Slorth 0.950452 View
ENSG00000140199 SLC12A6 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.950431 View
ENSG00000118046 STK11 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.950337 View
ENSG00000141736 ERBB2 ENSG00000184634 MED12 H. sapiens SSL Slorth 0.95033 View
ENSG00000078747 ITCH ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.950193 View
ENSG00000010810 FYN ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.950153 View
ENSG00000085832 EPS15 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.949919 View
ENSG00000070831 CDC42 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.949908 View
ENSG00000006468 ETV1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.94984 View
ENSG00000141736 ERBB2 ENSG00000244405 ETV5 H. sapiens SDL Slorth 0.949816 View