ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000132669 RIN2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.948116 View
ENSG00000141736 ERBB2 ENSG00000198836 OPA1 H. sapiens SSL Slorth 0.948066 View
ENSG00000141736 ERBB2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.94801 View
ENSG00000103479 RBL2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.948001 View
ENSG00000136936 XPA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.94793 View
ENSG00000141736 ERBB2 ENSG00000162367 TAL1 H. sapiens SSL Slorth 0.947927 View
ENSG00000141736 ERBB2 ENSG00000153561 RMND5A H. sapiens SDL Slorth 0.947852 View
ENSG00000016082 ISL1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.947744 View
ENSG00000141736 ERBB2 ENSG00000185386 MAPK11 H. sapiens SDL Slorth 0.947721 View
ENSG00000141736 ERBB2 ENSG00000215301 DDX3X H. sapiens SSL Slorth 0.947719 View
ENSG00000141736 ERBB2 ENSG00000178950 GAK H. sapiens SSL Slorth 0.947683 View
ENSG00000107581 EIF3A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.947636 View
ENSG00000138829 FBN2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.947578 View
ENSG00000099956 SMARCB1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.947555 View
ENSG00000141736 ERBB2 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.947515 View
ENSG00000141736 ERBB2 ENSG00000160293 VAV2 H. sapiens SDL Slorth 0.947483 View
ENSG00000049323 LTBP1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.947438 View
ENSG00000136997 MYC ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.947431 View
ENSG00000102978 POLR2C ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.947419 View
ENSG00000141736 ERBB2 ENSG00000168283 BMI1 H. sapiens SDL Slorth 0.947299 View
ENSG00000141736 ERBB2 ENSG00000175104 TRAF6 H. sapiens SSL Slorth 0.947282 View
ENSG00000141736 ERBB2 ENSG00000150593 PDCD4 H. sapiens SSL Slorth 0.947235 View
ENSG00000141736 ERBB2 ENSG00000185513 L3MBTL1 H. sapiens SDL Slorth 0.947192 View
ENSG00000053900 ANAPC4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.947076 View
ENSG00000141736 ERBB2 ENSG00000157087 ATP2B2 H. sapiens SSL Slorth 0.947058 View
ENSG00000136750 GAD2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.947044 View
ENSG00000082701 GSK3B ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.946976 View
ENSG00000140992 PDPK1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.946794 View
ENSG00000136875 PRPF4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.946712 View
ENSG00000073969 NSF ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.946615 View
ENSG00000066923 STAG3 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.946455 View
ENSG00000070718 AP3M2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.946428 View
ENSG00000129354 AP1M2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.946354 View
ENSG00000079999 KEAP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.946311 View
ENSG00000141736 ERBB2 ENSG00000158092 NCK1 H. sapiens SDL Slorth 0.946277 View
ENSG00000141736 ERBB2 ENSG00000168453 HR H. sapiens SDL Slorth 0.946221 View
ENSG00000087510 TFAP2C ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.946123 View
ENSG00000008196 TFAP2B ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.946123 View
ENSG00000124782 RREB1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.946081 View
ENSG00000061938 TNK2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.945973 View