ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000123124 WWP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.954701 View
ENSG00000116044 NFE2L2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.954686 View
ENSG00000141736 ERBB2 ENSG00000143514 TP53BP2 H. sapiens SSL Slorth 0.954635 View
ENSG00000141736 ERBB2 ENSG00000144381 HSPD1 H. sapiens SSL Slorth 0.954555 View
ENSG00000091831 ESR1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.954459 View
ENSG00000139998 RAB15 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.954415 View
ENSG00000141736 ERBB2 ENSG00000213672 NCKIPSD H. sapiens SDL Slorth 0.954387 View
ENSG00000141736 ERBB2 ENSG00000163938 GNL3 H. sapiens SSL Slorth 0.954315 View
ENSG00000141736 ERBB2 ENSG00000197157 SND1 H. sapiens SDL Slorth 0.95429 View
ENSG00000105204 DYRK1B ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.954288 View
ENSG00000079134 THOC1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.954233 View
ENSG00000141503 MINK1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.954133 View
ENSG00000101665 SMAD7 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.954125 View
ENSG00000141736 ERBB2 ENSG00000144554 FANCD2 H. sapiens SSL Slorth 0.954083 View
ENSG00000141736 ERBB2 ENSG00000141837 CACNA1A H. sapiens SSL Slorth 0.954068 View
ENSG00000141736 ERBB2 ENSG00000165280 VCP H. sapiens SSL Slorth 0.95406 View
ENSG00000079335 CDC14A ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.954042 View
ENSG00000124813 RUNX2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.95402 View
ENSG00000106346 USP42 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.953982 View
ENSG00000141736 ERBB2 ENSG00000143473 KCNH1 H. sapiens SDL Slorth 0.953933 View
ENSG00000136237 RAPGEF5 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.953932 View
ENSG00000141736 ERBB2 ENSG00000156052 GNAQ H. sapiens SDL Slorth 0.953917 View
ENSG00000141736 ERBB2 ENSG00000142208 AKT1 H. sapiens SDL Slorth 0.953917 View
ENSG00000101365 IDH3B ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.953873 View
ENSG00000141736 ERBB2 ENSG00000197122 SRC H. sapiens SDL Slorth 0.953583 View
ENSG00000141736 ERBB2 ENSG00000164402 SEPT8 H. sapiens SSL Slorth 0.953345 View
ENSG00000006451 RALA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.953261 View
ENSG00000140464 PML ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.953207 View
ENSG00000102317 RBM3 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.953201 View
ENSG00000141736 ERBB2 ENSG00000164104 HMGB2 H. sapiens SSL Slorth 0.952966 View
ENSG00000141736 ERBB2 ENSG00000166913 YWHAB H. sapiens SSL Slorth 0.952943 View
ENSG00000135624 CCT7 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.952932 View
ENSG00000141736 ERBB2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.952788 View
ENSG00000141736 ERBB2 ENSG00000177606 JUN H. sapiens SSL Slorth 0.952686 View
ENSG00000113240 CLK4 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.952594 View
ENSG00000055332 EIF2AK2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.952462 View
ENSG00000135597 REPS1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.952421 View
ENSG00000132964 CDK8 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.952411 View
ENSG00000141736 ERBB2 ENSG00000213585 VDAC1 H. sapiens SDL Slorth 0.952381 View
ENSG00000141736 ERBB2 ENSG00000145375 SPATA5 H. sapiens SSL Slorth 0.952355 View