ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000136238 RAC1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.96078 View
ENSG00000141736 ERBB2 ENSG00000151692 RNF144A H. sapiens SDL Slorth 0.960747 View
ENSG00000141736 ERBB2 ENSG00000164109 MAD2L1 H. sapiens SSL Slorth 0.960698 View
ENSG00000141736 ERBB2 ENSG00000168421 RHOH H. sapiens SDL Slorth 0.96068 View
ENSG00000141736 ERBB2 ENSG00000182968 SOX1 H. sapiens SDL Slorth 0.960646 View
ENSG00000141736 ERBB2 ENSG00000183684 ALYREF H. sapiens SSL Slorth 0.960599 View
ENSG00000141736 ERBB2 ENSG00000170027 YWHAG H. sapiens SSL Slorth 0.960532 View
ENSG00000141736 ERBB2 ENSG00000169800 RBMY1F H. sapiens SDL Slorth 0.960447 View
ENSG00000137486 ARRB1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.960432 View
ENSG00000141736 ERBB2 ENSG00000154237 LRRK1 H. sapiens SDL Slorth 0.960432 View
ENSG00000100239 PPP6R2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.960393 View
ENSG00000111540 RAB5B ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.960289 View
ENSG00000141736 ERBB2 ENSG00000152818 UTRN H. sapiens SDL Slorth 0.960215 View
ENSG00000141736 ERBB2 ENSG00000169756 LIMS1 H. sapiens SDL Slorth 0.960213 View
ENSG00000141736 ERBB2 ENSG00000168610 STAT3 H. sapiens SSL Slorth 0.960158 View
ENSG00000077935 SMC1B ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.960051 View
ENSG00000102996 MMP15 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.960031 View
ENSG00000077380 DYNC1I2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.960031 View
ENSG00000141736 ERBB2 ENSG00000150459 SAP18 H. sapiens SSL Slorth 0.959975 View
ENSG00000079156 OSBPL6 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.959949 View
ENSG00000112679 DUSP22 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.959946 View
ENSG00000117707 PROX1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.959945 View
ENSG00000141736 ERBB2 ENSG00000163930 BAP1 H. sapiens SSL Slorth 0.959833 View
ENSG00000104365 IKBKB ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.959826 View
ENSG00000065559 MAP2K4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.95981 View
ENSG00000141736 ERBB2 ENSG00000143384 MCL1 H. sapiens SDL Slorth 0.95979 View
ENSG00000141736 ERBB2 ENSG00000160803 UBQLN4 H. sapiens SSL Slorth 0.95973 View
ENSG00000075624 ACTB ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.959727 View
ENSG00000141736 ERBB2 ENSG00000179218 CALR H. sapiens SDL Slorth 0.959677 View
ENSG00000141736 ERBB2 ENSG00000169139 UBE2V2 H. sapiens SDL Slorth 0.95958 View
ENSG00000141736 ERBB2 ENSG00000143033 MTF2 H. sapiens SDL Slorth 0.959574 View
ENSG00000114062 UBE3A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.959567 View
ENSG00000141736 ERBB2 ENSG00000240771 ARHGEF25 H. sapiens SDL Slorth 0.95955 View
ENSG00000105287 PRKD2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.959524 View
ENSG00000141736 ERBB2 ENSG00000198625 MDM4 H. sapiens SSL Slorth 0.959484 View
ENSG00000141736 ERBB2 ENSG00000159496 RGL4 H. sapiens SDL Slorth 0.959484 View
ENSG00000141736 ERBB2 ENSG00000143344 RGL1 H. sapiens SDL Slorth 0.959484 View
ENSG00000096384 HSP90AB1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.959468 View
ENSG00000132383 RPA1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.959388 View
ENSG00000077092 RARB ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.959313 View