ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141736 ERBB2 ENSG00000254087 LYN H. sapiens SDL Slorth 0.957192 View
ENSG00000141736 ERBB2 ENSG00000185591 SP1 H. sapiens SSL Slorth 0.957177 View
ENSG00000141736 ERBB2 ENSG00000152818 UTRN H. sapiens SSL Slorth 0.957119 View
ENSG00000141736 ERBB2 ENSG00000164056 SPRY1 H. sapiens SDL Slorth 0.957016 View
ENSG00000141736 ERBB2 ENSG00000198742 SMURF1 H. sapiens SDL Slorth 0.956997 View
ENSG00000136238 RAC1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.956994 View
ENSG00000120539 MASTL ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.956951 View
ENSG00000136450 SRSF1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.956866 View
ENSG00000141736 ERBB2 ENSG00000170345 FOS H. sapiens SSL Slorth 0.956759 View
ENSG00000141736 ERBB2 ENSG00000145741 BTF3 H. sapiens SSL Slorth 0.956684 View
ENSG00000134982 APC ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.956645 View
ENSG00000141736 ERBB2 ENSG00000187735 TCEA1 H. sapiens SSL Slorth 0.956626 View
ENSG00000141736 ERBB2 ENSG00000185697 MYBL1 H. sapiens SDL Slorth 0.956438 View
ENSG00000141736 ERBB2 ENSG00000164924 YWHAZ H. sapiens SSL Slorth 0.956421 View
ENSG00000141736 ERBB2 ENSG00000143801 PSEN2 H. sapiens SDL Slorth 0.95637 View
ENSG00000132646 PCNA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.956132 View
ENSG00000140443 IGF1R ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.955861 View
ENSG00000141736 ERBB2 ENSG00000214517 PPME1 H. sapiens SDL Slorth 0.955768 View
ENSG00000133124 IRS4 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.955715 View
ENSG00000141736 ERBB2 ENSG00000142208 AKT1 H. sapiens SSL Slorth 0.955712 View
ENSG00000141736 ERBB2 ENSG00000143258 USP21 H. sapiens SDL Slorth 0.955624 View
ENSG00000141736 ERBB2 ENSG00000175093 SPSB4 H. sapiens SDL Slorth 0.955607 View
ENSG00000134853 PDGFRA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.955591 View
ENSG00000132386 SERPINF1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.955584 View
ENSG00000141736 ERBB2 ENSG00000155849 ELMO1 H. sapiens SDL Slorth 0.955419 View
ENSG00000141736 ERBB2 ENSG00000172367 PDZD3 H. sapiens SDL Slorth 0.955307 View
ENSG00000115221 ITGB6 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.955281 View
ENSG00000141736 ERBB2 ENSG00000163513 TGFBR2 H. sapiens SDL Slorth 0.955256 View
ENSG00000141736 ERBB2 ENSG00000165671 NSD1 H. sapiens SDL Slorth 0.954912 View
ENSG00000141736 ERBB2 ENSG00000166501 PRKCB H. sapiens SDL Slorth 0.954912 View
ENSG00000141736 ERBB2 ENSG00000185122 HSF1 H. sapiens SDL Slorth 0.954909 View
ENSG00000111875 ASF1A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.954826 View
ENSG00000141736 ERBB2 ENSG00000179262 RAD23A H. sapiens SSL Slorth 0.954821 View
ENSG00000141736 ERBB2 ENSG00000180370 PAK2 H. sapiens SDL Slorth 0.954814 View
ENSG00000117748 RPA2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.95481 View
ENSG00000102882 MAPK3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.954803 View
ENSG00000141736 ERBB2 ENSG00000158828 PINK1 H. sapiens SSL Slorth 0.954788 View
ENSG00000141736 ERBB2 ENSG00000170734 POLH H. sapiens SSL Slorth 0.954743 View
ENSG00000127022 CANX ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.954738 View
ENSG00000139219 COL2A1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.954707 View