ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141736 ERBB2 ENSG00000171848 RRM2 H. sapiens SSL BioGRID 1.0 View
ENSG00000141736 ERBB2 ENSG00000197122 SRC H. sapiens SSL BioGRID 1.0 View
ENSG00000141736 ERBB2 ENSG00000167900 TK1 H. sapiens SSL BioGRID 1.0 View
ENSG00000141736 ERBB2 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000089685 BIRC5 ENSG00000141736 ERBB2 H. sapiens SSL BioGRID 1.0 View
ENSG00000148660 CAMK2G ENSG00000141736 ERBB2 H. sapiens SSL BioGRID 1.0 View
ENSG00000164045 CDC25A ENSG00000141736 ERBB2 H. sapiens SSL BioGRID 1.0 View
ENSG00000167258 CDK12 ENSG00000141736 ERBB2 H. sapiens SSL BioGRID 1.0 View
ENSG00000135446 CDK4 ENSG00000141736 ERBB2 H. sapiens SSL BioGRID 1.0 View
ENSG00000183765 CHEK2 ENSG00000141736 ERBB2 H. sapiens SSL BioGRID 1.0 View
ENSG00000141736 ERBB2 ENSG00000068078 FGFR3 H. sapiens SSL BioGRID 1.0 View
ENSG00000141736 ERBB2 ENSG00000233276 GPX1 H. sapiens SSL BioGRID 1.0 View
ENSG00000141736 ERBB2 ENSG00000051382 PIK3CB H. sapiens SSL BioGRID 1.0 View
ENSG00000141736 ERBB2 ENSG00000253729 PRKDC H. sapiens SSL BioGRID 1.0 View
ENSG00000005339 CREBBP ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.991978 View
ENSG00000012048 BRCA1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.991925 View
ENSG00000116478 HDAC1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.988276 View
ENSG00000100393 EP300 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.986497 View
ENSG00000141510 TP53 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.982746 View
ENSG00000141736 ERBB2 ENSG00000184900 SUMO3 H. sapiens SSL Slorth 0.980893 View
ENSG00000080824 HSP90AA1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.980379 View
ENSG00000109670 FBXW7 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.980184 View
ENSG00000141736 ERBB2 ENSG00000145386 CCNA2 H. sapiens SSL Slorth 0.980183 View
ENSG00000141736 ERBB2 ENSG00000172977 KAT5 H. sapiens SSL Slorth 0.979952 View
ENSG00000141736 ERBB2 ENSG00000168496 FEN1 H. sapiens SSL Slorth 0.979408 View
ENSG00000141736 ERBB2 ENSG00000159461 AMFR H. sapiens SDL Slorth 0.978801 View
ENSG00000141736 ERBB2 ENSG00000145604 SKP2 H. sapiens SSL Slorth 0.978487 View
ENSG00000141736 ERBB2 ENSG00000158402 CDC25C H. sapiens SSL Slorth 0.978467 View
ENSG00000141736 ERBB2 ENSG00000175387 SMAD2 H. sapiens SSL Slorth 0.978325 View
ENSG00000141736 ERBB2 ENSG00000151694 ADAM17 H. sapiens SDL Slorth 0.978293 View
ENSG00000141736 ERBB2 ENSG00000159216 RUNX1 H. sapiens SSL Slorth 0.978157 View
ENSG00000141736 ERBB2 ENSG00000197299 BLM H. sapiens SSL Slorth 0.978093 View
ENSG00000141736 ERBB2 ENSG00000198561 CTNND1 H. sapiens SDL Slorth 0.977949 View
ENSG00000141736 ERBB2 ENSG00000156299 TIAM1 H. sapiens SDL Slorth 0.977867 View
ENSG00000141736 ERBB2 ENSG00000166483 WEE1 H. sapiens SSL Slorth 0.977795 View
ENSG00000141736 ERBB2 ENSG00000177889 UBE2N H. sapiens SSL Slorth 0.977524 View
ENSG00000141646 SMAD4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.977354 View
ENSG00000141736 ERBB2 ENSG00000172531 PPP1CA H. sapiens SSL Slorth 0.977293 View
ENSG00000141736 ERBB2 ENSG00000150991 UBC H. sapiens SDL Slorth 0.977202 View
ENSG00000121022 COPS5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.97688 View