ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000106327 TFR2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.937772 View
ENSG00000010671 BTK ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.937745 View
ENSG00000106462 EZH2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.93773 View
ENSG00000106355 LSM5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.937696 View
ENSG00000141736 ERBB2 ENSG00000157349 DDX19B H. sapiens SSL Slorth 0.937692 View
ENSG00000141736 ERBB2 ENSG00000166192 SENP8 H. sapiens SDL Slorth 0.937575 View
ENSG00000026103 FAS ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.937539 View
ENSG00000136937 NCBP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.937416 View
ENSG00000141736 ERBB2 ENSG00000198373 WWP2 H. sapiens SDL Slorth 0.937278 View
ENSG00000124486 USP9X ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.937236 View
ENSG00000070831 CDC42 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.937214 View
ENSG00000127445 PIN1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.937198 View
ENSG00000141736 ERBB2 ENSG00000163558 PRKCI H. sapiens SDL Slorth 0.937112 View
ENSG00000141736 ERBB2 ENSG00000147010 SH3KBP1 H. sapiens SDL Slorth 0.937005 View
ENSG00000095397 WHRN ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.93698 View
ENSG00000117713 ARID1A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.936761 View
ENSG00000141736 ERBB2 ENSG00000148737 TCF7L2 H. sapiens SDL Slorth 0.936634 View
ENSG00000114503 NCBP2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.936602 View
ENSG00000134308 YWHAQ ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.936581 View
ENSG00000141736 ERBB2 ENSG00000143190 POU2F1 H. sapiens SSL Slorth 0.93658 View
ENSG00000141736 ERBB2 ENSG00000188021 UBQLN2 H. sapiens SDL Slorth 0.93628 View
ENSG00000141736 ERBB2 ENSG00000150995 ITPR1 H. sapiens SDL Slorth 0.936241 View
ENSG00000126785 RHOJ ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.936132 View
ENSG00000141736 ERBB2 ENSG00000241837 ATP5O H. sapiens SSL Slorth 0.936089 View
ENSG00000087274 ADD1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.935886 View
ENSG00000114315 HES1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.935843 View
ENSG00000140564 FURIN ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.935843 View
ENSG00000141736 ERBB2 ENSG00000183020 AP2A2 H. sapiens SDL Slorth 0.935835 View
ENSG00000141736 ERBB2 ENSG00000164104 HMGB2 H. sapiens SDL Slorth 0.935692 View
ENSG00000122406 RPL5 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.935543 View
ENSG00000063660 GPC1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.935509 View
ENSG00000075785 RAB7A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.935193 View
ENSG00000095015 MAP3K1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.935158 View
ENSG00000100852 ARHGAP5 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.935101 View
ENSG00000109320 NFKB1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.935092 View
ENSG00000141736 ERBB2 ENSG00000151532 VTI1A H. sapiens SDL Slorth 0.935038 View
ENSG00000126261 UBA2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.935013 View
ENSG00000104695 PPP2CB ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.934962 View
ENSG00000112319 EYA4 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.934886 View
ENSG00000120438 TCP1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.934858 View