ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141736 ERBB2 ENSG00000196923 PDLIM7 H. sapiens SDL Slorth 0.934799 View
ENSG00000141736 ERBB2 ENSG00000165806 CASP7 H. sapiens SDL Slorth 0.934771 View
ENSG00000141736 ERBB2 ENSG00000162775 RBM15 H. sapiens SDL Slorth 0.934718 View
ENSG00000067606 PRKCZ ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.934646 View
ENSG00000137825 ITPKA ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.934597 View
ENSG00000141736 ERBB2 ENSG00000147316 MCPH1 H. sapiens SDL Slorth 0.934509 View
ENSG00000141736 ERBB2 ENSG00000163399 ATP1A1 H. sapiens SSL Slorth 0.934443 View
ENSG00000078114 NEBL ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.934434 View
ENSG00000141736 ERBB2 ENSG00000198793 MTOR H. sapiens SDL Slorth 0.934397 View
ENSG00000141736 ERBB2 ENSG00000196839 ADA H. sapiens SSL Slorth 0.934211 View
ENSG00000141543 EIF4A3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.934174 View
ENSG00000080986 NDC80 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.934135 View
ENSG00000141736 ERBB2 ENSG00000161800 RACGAP1 H. sapiens SDL Slorth 0.93411 View
ENSG00000141736 ERBB2 ENSG00000161956 SENP3 H. sapiens SSL Slorth 0.9341 View
ENSG00000141736 ERBB2 ENSG00000164077 MON1A H. sapiens SDL Slorth 0.934074 View
ENSG00000141736 ERBB2 ENSG00000197579 TOPORS H. sapiens SSL Slorth 0.933889 View
ENSG00000141736 ERBB2 ENSG00000181449 SOX2 H. sapiens SDL Slorth 0.93372 View
ENSG00000141736 ERBB2 ENSG00000163558 PRKCI H. sapiens SSL Slorth 0.933703 View
ENSG00000141736 ERBB2 ENSG00000198909 MAP3K3 H. sapiens SSL Slorth 0.933692 View
ENSG00000141736 ERBB2 ENSG00000149273 RPS3 H. sapiens SDL Slorth 0.933645 View
ENSG00000141736 ERBB2 ENSG00000169967 MAP3K2 H. sapiens SSL Slorth 0.933604 View
ENSG00000141736 ERBB2 ENSG00000169100 SLC25A6 H. sapiens SSL Slorth 0.933583 View
ENSG00000141736 ERBB2 ENSG00000152104 PTPN14 H. sapiens SSL Slorth 0.933509 View
ENSG00000114867 EIF4G1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.933494 View
ENSG00000141736 ERBB2 ENSG00000188906 LRRK2 H. sapiens SDL Slorth 0.933483 View
ENSG00000141736 ERBB2 ENSG00000173757 STAT5B H. sapiens SDL Slorth 0.933061 View
ENSG00000072062 PRKACA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.933006 View
ENSG00000105568 PPP2R1A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.932994 View
ENSG00000141736 ERBB2 ENSG00000153147 SMARCA5 H. sapiens SSL Slorth 0.932952 View
ENSG00000135341 MAP3K7 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.93291 View
ENSG00000141736 ERBB2 ENSG00000160691 SHC1 H. sapiens SSL Slorth 0.932901 View
ENSG00000141736 ERBB2 ENSG00000178568 ERBB4 H. sapiens SDL Slorth 0.932894 View
ENSG00000116478 HDAC1 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.932892 View
ENSG00000141736 ERBB2 ENSG00000160867 FGFR4 H. sapiens SDL Slorth 0.932875 View
ENSG00000141736 ERBB2 ENSG00000156508 EEF1A1 H. sapiens SDL Slorth 0.932801 View
ENSG00000141736 ERBB2 ENSG00000158169 FANCC H. sapiens SDL Slorth 0.93279 View
ENSG00000141736 ERBB2 ENSG00000165684 SNAPC4 H. sapiens SDL Slorth 0.932769 View
ENSG00000087995 METTL2A ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.932706 View
ENSG00000100906 NFKBIA ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.932535 View
ENSG00000117222 RBBP5 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.932402 View