ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000001167 NFYA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.932304 View
ENSG00000141736 ERBB2 ENSG00000164116 GUCY1A3 H. sapiens SDL Slorth 0.932269 View
ENSG00000141736 ERBB2 ENSG00000196235 SUPT5H H. sapiens SSL Slorth 0.932229 View
ENSG00000130699 TAF4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.932192 View
ENSG00000124164 VAPB ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.931809 View
ENSG00000141736 ERBB2 ENSG00000160803 UBQLN4 H. sapiens SDL Slorth 0.931515 View
ENSG00000141736 ERBB2 ENSG00000165637 VDAC2 H. sapiens SSL Slorth 0.931489 View
ENSG00000135776 ABCB10 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.93145 View
ENSG00000063244 U2AF2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.931407 View
ENSG00000125084 WNT1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.931397 View
ENSG00000141736 ERBB2 ENSG00000147416 ATP6V1B2 H. sapiens SSL Slorth 0.931318 View
ENSG00000130177 CDC16 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.931304 View
ENSG00000110092 CCND1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.931146 View
ENSG00000141736 ERBB2 ENSG00000197943 PLCG2 H. sapiens SDL Slorth 0.931144 View
ENSG00000141736 ERBB2 ENSG00000171960 PPIH H. sapiens SSL Slorth 0.931101 View
ENSG00000102034 ELF4 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.931005 View
ENSG00000128739 SNRPN ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.930987 View
ENSG00000134438 RAX ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.930965 View
ENSG00000141736 ERBB2 ENSG00000171094 ALK H. sapiens SDL Slorth 0.930845 View
ENSG00000121774 KHDRBS1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.930803 View
ENSG00000068024 HDAC4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.930776 View
ENSG00000100228 RAB36 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.930745 View
ENSG00000138594 TMOD3 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.930745 View
ENSG00000085185 BCORL1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.930745 View
ENSG00000141736 ERBB2 ENSG00000170248 PDCD6IP H. sapiens SDL Slorth 0.930628 View
ENSG00000134871 COL4A2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.930609 View
ENSG00000141736 ERBB2 ENSG00000180198 RCC1 H. sapiens SSL Slorth 0.930582 View
ENSG00000141736 ERBB2 ENSG00000165527 ARF6 H. sapiens SDL Slorth 0.930573 View
ENSG00000141736 ERBB2 ENSG00000221829 FANCG H. sapiens SDL Slorth 0.930556 View
ENSG00000141736 ERBB2 ENSG00000178607 ERN1 H. sapiens SSL Slorth 0.930498 View
ENSG00000123094 RASSF8 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.930412 View
ENSG00000122966 CIT ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.930376 View
ENSG00000141736 ERBB2 ENSG00000165672 PRDX3 H. sapiens SSL Slorth 0.930295 View
ENSG00000141736 ERBB2 ENSG00000174775 HRAS H. sapiens SSL Slorth 0.930283 View
ENSG00000135090 TAOK3 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.93024 View
ENSG00000070778 PTPN21 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.930197 View
ENSG00000139668 WDFY2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.930125 View
ENSG00000104738 MCM4 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.930101 View
ENSG00000141736 ERBB2 ENSG00000147162 OGT H. sapiens SDL Slorth 0.929971 View
ENSG00000105976 MET ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.929955 View