ERBB2

ENSG00000141736 - H. sapiens

Pathways

Go term Description
GO:0001042 RNA polymerase I core binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0019838 growth factor binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PERTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB Receptor protein-tyrosine kinase erbB-2 inhibitor
TRASTUZUMAB EMTANSINE Tubulin inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
breast
ovarian
other tumour types
NSCLC
gastric

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000005882 PDK2 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.92666 View
ENSG00000137166 FOXP4 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.92666 View
ENSG00000007264 MATK ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.926509 View
ENSG00000141736 ERBB2 ENSG00000268173 AC007192.4 H. sapiens SDL Slorth 0.926482 View
ENSG00000140538 NTRK3 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.926468 View
ENSG00000069869 NEDD4 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.926389 View
ENSG00000141736 ERBB2 ENSG00000182944 EWSR1 H. sapiens SSL Slorth 0.926361 View
ENSG00000141736 ERBB2 ENSG00000178999 AURKB H. sapiens SSL Slorth 0.926289 View
ENSG00000141736 ERBB2 ENSG00000183454 GRIN2A H. sapiens SDL Slorth 0.926263 View
ENSG00000140750 ARHGAP17 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.926245 View
ENSG00000141736 ERBB2 ENSG00000185950 IRS2 H. sapiens SDL Slorth 0.926159 View
ENSG00000141736 ERBB2 ENSG00000147403 RPL10 H. sapiens SDL Slorth 0.92611 View
ENSG00000141736 ERBB2 ENSG00000167658 EEF2 H. sapiens SDL Slorth 0.926088 View
ENSG00000124762 CDKN1A ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.926063 View
ENSG00000141736 ERBB2 ENSG00000158290 CUL4B H. sapiens SSL Slorth 0.926016 View
ENSG00000141736 ERBB2 ENSG00000163041 H3F3A H. sapiens SSL Slorth 0.925931 View
ENSG00000141736 ERBB2 ENSG00000182606 TRAK1 H. sapiens SDL Slorth 0.925776 View
ENSG00000141736 ERBB2 ENSG00000166598 HSP90B1 H. sapiens SDL Slorth 0.92575 View
ENSG00000058404 CAMK2B ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.925713 View
ENSG00000075089 ACTR6 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.925681 View
ENSG00000141736 ERBB2 ENSG00000196911 KPNA5 H. sapiens SDL Slorth 0.925677 View
ENSG00000118689 FOXO3 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.925671 View
ENSG00000048540 LMO3 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.925578 View
ENSG00000001626 CFTR ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.925572 View
ENSG00000117400 MPL ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.925548 View
ENSG00000115216 NRBP1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.925541 View
ENSG00000070756 PABPC1 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.925533 View
ENSG00000141736 ERBB2 ENSG00000163840 DTX3L H. sapiens SSL Slorth 0.925528 View
ENSG00000141736 ERBB2 ENSG00000172725 CORO1B H. sapiens SSL Slorth 0.925307 View
ENSG00000141736 ERBB2 ENSG00000170836 PPM1D H. sapiens SDL Slorth 0.925263 View
ENSG00000141736 ERBB2 ENSG00000170142 UBE2E1 H. sapiens SSL Slorth 0.925185 View
ENSG00000141736 ERBB2 ENSG00000152669 CCNO H. sapiens SDL Slorth 0.925185 View
ENSG00000141736 ERBB2 ENSG00000163161 ERCC3 H. sapiens SSL Slorth 0.925164 View
ENSG00000141736 ERBB2 ENSG00000174672 BRSK2 H. sapiens SDL Slorth 0.924975 View
ENSG00000141736 ERBB2 ENSG00000145715 RASA1 H. sapiens SDL Slorth 0.924802 View
ENSG00000064489 BORCS8-MEF2B ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.924491 View
ENSG00000110148 CCKBR ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.924491 View
ENSG00000101132 PFDN4 ENSG00000141736 ERBB2 H. sapiens SDL Slorth 0.924266 View
ENSG00000141736 ERBB2 ENSG00000149136 SSRP1 H. sapiens SDL Slorth 0.924251 View
ENSG00000141736 ERBB2 ENSG00000196218 RYR1 H. sapiens SSL Slorth 0.924155 View