HES1 - ERBB2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
HES1	ENSG00000114315	No diseases in record	No drugs in record	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein homodimerization activity histone deacetylase binding sequence-specific DNA binding chaperone binding N-box binding oxysterol binding lipid binding sterol transporter activity	lin-22 (C. elegans) h (D. melanogaster) dpn (D. melanogaster)
ERBB2	ENSG00000141736	breast ovarian other tumour types NSCLC gastric	AFATINIB LAPATINIB PERTUZUMAB TRASTUZUMAB TRASTUZUMAB EMTANSINE VANDETANIB	RNA polymerase I core binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity transmembrane signaling receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding protein C-terminus binding protein phosphatase binding identical protein binding ErbB-3 class receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity protein dimerization activity growth factor binding	let-23 (C. elegans) Egfr (D. melanogaster)