TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000182866 LCK ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.876715 View
ENSG00000140682 TGFB1I1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.876503 View
ENSG00000176105 YES1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.876462 View
ENSG00000198900 TOP1 ENSG00000254772 EEF1G H. sapiens SSL Slorth 0.876349 View
ENSG00000083093 PALB2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.876223 View
ENSG00000072310 SREBF1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.87619 View
ENSG00000177189 RPS6KA3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.876175 View
ENSG00000077782 FGFR1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.876128 View
ENSG00000108468 CBX1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.876048 View
ENSG00000155097 ATP6V1C1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.875896 View
ENSG00000166598 HSP90B1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.875876 View
ENSG00000100201 DDX17 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.87561 View
ENSG00000113658 SMAD5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.875564 View
ENSG00000197275 RAD54B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.875214 View
ENSG00000160075 SSU72 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.874839 View
ENSG00000177613 CSTF2T ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.874698 View
ENSG00000074211 PPP2R2C ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.874598 View
ENSG00000109911 ELP4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.874246 View
ENSG00000107882 SUFU ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.874007 View
ENSG00000108946 PRKAR1A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.874 View
ENSG00000110321 EIF4G2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.873992 View
ENSG00000037474 NSUN2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.873773 View
ENSG00000186432 KPNA4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.873677 View
ENSG00000007168 PAFAH1B1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.873606 View
ENSG00000185236 RAB11B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.873516 View
ENSG00000184304 PRKD1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.873428 View
ENSG00000146872 TLK2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.873426 View
ENSG00000155959 VBP1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.873092 View
ENSG00000155363 MOV10 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.873083 View
ENSG00000078061 ARAF ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.872995 View
ENSG00000179094 PER1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.872813 View
ENSG00000168411 RFWD3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.87263 View
ENSG00000105248 CCDC94 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.872433 View
ENSG00000089280 FUS ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.872292 View
ENSG00000130956 HABP4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.872226 View
ENSG00000197498 RPF2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.87192 View
ENSG00000175550 DRAP1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.871858 View
ENSG00000198700 IPO9 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.871778 View
ENSG00000178295 GEN1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.871456 View
ENSG00000196305 IARS ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.871245 View