RET

ENSG00000165731 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004872 receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005178 integrin binding

Drugs

Drug name Description
CABOZANTINIB
LENVATINIB
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
medullary thyroid
papillary thyroid
pheochromocytoma
NSCLC
Spitzoid tumour

Orthologs

No orthologs in record

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000165731 RET ENSG00000196305 IARS H. sapiens SSL Slorth 0.801153 View
ENSG00000138190 EXOC6 ENSG00000165731 RET H. sapiens SSL Slorth 0.800129 View
ENSG00000109819 PPARGC1A ENSG00000165731 RET H. sapiens SSL Slorth 0.800047 View
ENSG00000138696 BMPR1B ENSG00000165731 RET H. sapiens SSL Slorth 0.799932 View
ENSG00000165731 RET ENSG00000188612 SUMO2 H. sapiens SSL Slorth 0.799802 View
ENSG00000119318 RAD23B ENSG00000165731 RET H. sapiens SSL Slorth 0.799423 View
ENSG00000155959 VBP1 ENSG00000165731 RET H. sapiens SSL Slorth 0.798777 View
ENSG00000141384 TAF4B ENSG00000165731 RET H. sapiens SSL Slorth 0.79865 View
ENSG00000165731 RET ENSG00000178607 ERN1 H. sapiens SSL Slorth 0.798529 View
ENSG00000165731 RET ENSG00000187266 EPOR H. sapiens SSL Slorth 0.798077 View
ENSG00000112242 E2F3 ENSG00000165731 RET H. sapiens SSL Slorth 0.797977 View
ENSG00000165731 RET ENSG00000169252 ADRB2 H. sapiens SSL Slorth 0.797945 View
ENSG00000008735 MAPK8IP2 ENSG00000165731 RET H. sapiens SSL Slorth 0.797711 View
ENSG00000160551 TAOK1 ENSG00000165731 RET H. sapiens SSL Slorth 0.797497 View
ENSG00000165731 RET ENSG00000187608 ISG15 H. sapiens SSL Slorth 0.797412 View
ENSG00000127314 RAP1B ENSG00000165731 RET H. sapiens SSL Slorth 0.796926 View
ENSG00000136854 STXBP1 ENSG00000165731 RET H. sapiens SSL Slorth 0.796645 View
ENSG00000117713 ARID1A ENSG00000165731 RET H. sapiens SSL Slorth 0.796585 View
ENSG00000165731 RET ENSG00000166167 BTRC H. sapiens SSL Slorth 0.795467 View
ENSG00000118503 TNFAIP3 ENSG00000165731 RET H. sapiens SSL Slorth 0.795402 View
ENSG00000100387 RBX1 ENSG00000165731 RET H. sapiens SSL Slorth 0.795201 View
ENSG00000161270 NPHS1 ENSG00000165731 RET H. sapiens SSL Slorth 0.794341 View
ENSG00000165731 RET ENSG00000170248 PDCD6IP H. sapiens SSL Slorth 0.794033 View
ENSG00000165731 RET ENSG00000196628 TCF4 H. sapiens SSL Slorth 0.793641 View
ENSG00000020922 MRE11 ENSG00000165731 RET H. sapiens SSL Slorth 0.793463 View
ENSG00000136527 TRA2B ENSG00000165731 RET H. sapiens SSL Slorth 0.793096 View
ENSG00000165731 RET ENSG00000181788 SIAH2 H. sapiens SSL Slorth 0.792713 View
ENSG00000123908 AGO2 ENSG00000165731 RET H. sapiens SSL Slorth 0.792525 View
ENSG00000156304 SCAF4 ENSG00000165731 RET H. sapiens SSL Slorth 0.792429 View
ENSG00000116350 SRSF4 ENSG00000165731 RET H. sapiens SSL Slorth 0.792424 View
ENSG00000101199 ARFGAP1 ENSG00000165731 RET H. sapiens SSL Slorth 0.792118 View
ENSG00000137309 HMGA1 ENSG00000165731 RET H. sapiens SSL Slorth 0.791726 View
ENSG00000160789 LMNA ENSG00000165731 RET H. sapiens SSL Slorth 0.791669 View
ENSG00000113812 ACTR8 ENSG00000165731 RET H. sapiens SSL Slorth 0.791643 View
ENSG00000078018 MAP2 ENSG00000165731 RET H. sapiens SSL Slorth 0.791405 View
ENSG00000116584 ARHGEF2 ENSG00000165731 RET H. sapiens SSL Slorth 0.791268 View
ENSG00000091009 RBM27 ENSG00000165731 RET H. sapiens SSL Slorth 0.791182 View
ENSG00000165731 RET ENSG00000170144 HNRNPA3 H. sapiens SSL Slorth 0.790926 View
ENSG00000108510 MED13 ENSG00000165731 RET H. sapiens SSL Slorth 0.790046 View
ENSG00000090316 MAEA ENSG00000165731 RET H. sapiens SSL Slorth 0.78937 View