JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000162434 JAK1 ENSG00000179094 PER1 H. sapiens SSL Slorth 0.777382 View
ENSG00000162434 JAK1 ENSG00000178573 MAF H. sapiens SSL Slorth 0.777208 View
ENSG00000162434 JAK1 ENSG00000169710 FASN H. sapiens SSL Slorth 0.777085 View
ENSG00000162434 JAK1 ENSG00000172175 MALT1 H. sapiens SSL Slorth 0.776918 View
ENSG00000162434 JAK1 ENSG00000182606 TRAK1 H. sapiens SSL Slorth 0.776769 View
ENSG00000162434 JAK1 ENSG00000198612 COPS8 H. sapiens SSL Slorth 0.776592 View
ENSG00000162434 JAK1 ENSG00000184260 HIST2H2AC H. sapiens SSL Slorth 0.776548 View
ENSG00000042088 TDP1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.776403 View
ENSG00000162434 JAK1 ENSG00000198890 PRMT6 H. sapiens SSL Slorth 0.776387 View
ENSG00000162434 JAK1 ENSG00000213465 ARL2 H. sapiens SSL Slorth 0.77629 View
ENSG00000162434 JAK1 ENSG00000167004 PDIA3 H. sapiens SSL Slorth 0.776108 View
ENSG00000065150 IPO5 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.775806 View
ENSG00000162434 JAK1 ENSG00000177666 PNPLA2 H. sapiens SSL Slorth 0.775701 View
ENSG00000143106 PSMA5 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.775557 View
ENSG00000150995 ITPR1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.775106 View
ENSG00000162434 JAK1 ENSG00000180098 TRNAU1AP H. sapiens SSL Slorth 0.774796 View
ENSG00000108883 EFTUD2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.77477 View
ENSG00000162434 JAK1 ENSG00000174371 EXO1 H. sapiens SSL Slorth 0.774635 View
ENSG00000162434 JAK1 ENSG00000196924 FLNA H. sapiens SSL Slorth 0.774405 View
ENSG00000117758 STX12 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.773576 View
ENSG00000099940 SNAP29 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.773322 View
ENSG00000162434 JAK1 ENSG00000198873 GRK5 H. sapiens SSL Slorth 0.773308 View
ENSG00000162434 JAK1 ENSG00000203879 GDI1 H. sapiens SSL Slorth 0.773038 View
ENSG00000162434 JAK1 ENSG00000205302 SNX2 H. sapiens SSL Slorth 0.772837 View
ENSG00000162434 JAK1 ENSG00000183943 PRKX H. sapiens SSL Slorth 0.772728 View
ENSG00000162434 JAK1 ENSG00000182199 SHMT2 H. sapiens SSL Slorth 0.772723 View
ENSG00000162434 JAK1 ENSG00000176749 CDK5R1 H. sapiens SSL Slorth 0.772586 View
ENSG00000107341 UBE2R2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.772565 View
ENSG00000162434 JAK1 ENSG00000167005 NUDT21 H. sapiens SSL Slorth 0.772508 View
ENSG00000071539 TRIP13 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.77224 View
ENSG00000162434 JAK1 ENSG00000180353 HCLS1 H. sapiens SSL Slorth 0.772118 View
ENSG00000161638 ITGA5 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.771912 View
ENSG00000074800 ENO1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.771904 View
ENSG00000162434 JAK1 ENSG00000165699 TSC1 H. sapiens SSL Slorth 0.771886 View
ENSG00000121966 CXCR4 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.771597 View
ENSG00000136986 DERL1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.771499 View
ENSG00000118007 STAG1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.77147 View
ENSG00000131263 RLIM ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.771055 View
ENSG00000007944 MYLIP ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.771046 View
ENSG00000162434 JAK1 ENSG00000173848 NET1 H. sapiens SSL Slorth 0.770779 View