JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000162434 JAK1 ENSG00000164754 RAD21 H. sapiens SSL Slorth 0.811955 View
ENSG00000162434 JAK1 ENSG00000171720 HDAC3 H. sapiens SSL Slorth 0.811541 View
ENSG00000092853 CLSPN ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.811505 View
ENSG00000065675 PRKCQ ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.810973 View
ENSG00000162434 JAK1 ENSG00000239857 GET4 H. sapiens SSL Slorth 0.810888 View
ENSG00000101849 TBL1X ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.810794 View
ENSG00000090020 SLC9A1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.810788 View
ENSG00000162434 JAK1 ENSG00000166888 STAT6 H. sapiens SSL Slorth 0.810673 View
ENSG00000148688 RPP30 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.810666 View
ENSG00000162434 JAK1 ENSG00000173542 MOB1B H. sapiens SSL Slorth 0.810532 View
ENSG00000162434 JAK1 ENSG00000163840 DTX3L H. sapiens SSL Slorth 0.809756 View
ENSG00000162434 JAK1 ENSG00000198959 TGM2 H. sapiens SSL Slorth 0.809673 View
ENSG00000138081 FBXO11 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.809597 View
ENSG00000162434 JAK1 ENSG00000163655 GMPS H. sapiens SSL Slorth 0.809511 View
ENSG00000100722 ZC3H14 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.809081 View
ENSG00000130479 MAP1S ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.809066 View
ENSG00000113810 SMC4 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.809041 View
ENSG00000143761 ARF1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.808926 View
ENSG00000149100 EIF3M ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.808794 View
ENSG00000142453 CARM1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.808754 View
ENSG00000141522 ARHGDIA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.808629 View
ENSG00000144381 HSPD1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.808597 View
ENSG00000162434 JAK1 ENSG00000180176 TH H. sapiens SSL Slorth 0.808317 View
ENSG00000121152 NCAPH ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.807791 View
ENSG00000104884 ERCC2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.807456 View
ENSG00000137267 TUBB2A ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.807388 View
ENSG00000162434 JAK1 ENSG00000171723 GPHN H. sapiens SSL Slorth 0.807035 View
ENSG00000162434 JAK1 ENSG00000173327 MAP3K11 H. sapiens SSL Slorth 0.806852 View
ENSG00000162434 JAK1 ENSG00000176890 TYMS H. sapiens SSL Slorth 0.806721 View
ENSG00000162434 JAK1 ENSG00000184557 SOCS3 H. sapiens SSL Slorth 0.806563 View
ENSG00000125971 DYNLRB1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.80653 View
ENSG00000109805 NCAPG ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.806287 View
ENSG00000090316 MAEA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.806281 View
ENSG00000107201 DDX58 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.806249 View
ENSG00000136279 DBNL ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.806127 View
ENSG00000162434 JAK1 ENSG00000182979 MTA1 H. sapiens SSL Slorth 0.806102 View
ENSG00000162434 JAK1 ENSG00000254505 CHMP4A H. sapiens SSL Slorth 0.806088 View
ENSG00000162434 JAK1 ENSG00000169679 BUB1 H. sapiens SSL Slorth 0.806066 View
ENSG00000162434 JAK1 ENSG00000175931 UBE2O H. sapiens SSL Slorth 0.805658 View
ENSG00000162434 JAK1 ENSG00000173757 STAT5B H. sapiens SSL Slorth 0.80565 View