JAK1

ENSG00000162434 - H. sapiens

Pathways

Go term Description
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0046872 metal ion binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000155438 NIFK ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.770644 View
ENSG00000049245 VAMP3 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.770571 View
ENSG00000108061 SHOC2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.770125 View
ENSG00000162434 JAK1 ENSG00000185811 IKZF1 H. sapiens SSL Slorth 0.769376 View
ENSG00000007255 TRAPPC6A ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.768979 View
ENSG00000158828 PINK1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.76894 View
ENSG00000137193 PIM1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.768767 View
ENSG00000133026 MYH10 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.768451 View
ENSG00000055044 NOP58 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.768418 View
ENSG00000101197 BIRC7 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.76836 View
ENSG00000078668 VDAC3 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.768129 View
ENSG00000084234 APLP2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.767753 View
ENSG00000065665 SEC61A2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.767632 View
ENSG00000064703 DDX20 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.767467 View
ENSG00000162434 JAK1 ENSG00000188603 CLN3 H. sapiens SSL Slorth 0.767462 View
ENSG00000138592 USP8 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.767287 View
ENSG00000162434 JAK1 ENSG00000196531 NACA H. sapiens SSL Slorth 0.766726 View
ENSG00000117450 PRDX1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.766724 View
ENSG00000107651 SEC23IP ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.766652 View
ENSG00000137055 PLAA ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.76659 View
ENSG00000007171 NOS2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.766503 View
ENSG00000115524 SF3B1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.766148 View
ENSG00000141384 TAF4B ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.765999 View
ENSG00000162434 JAK1 ENSG00000171105 INSR H. sapiens SSL Slorth 0.765912 View
ENSG00000115946 PNO1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.765853 View
ENSG00000105968 H2AFV ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.765682 View
ENSG00000162434 JAK1 ENSG00000178252 WDR6 H. sapiens SSL Slorth 0.76551 View
ENSG00000135766 EGLN1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.765399 View
ENSG00000113460 BRIX1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.765355 View
ENSG00000124216 SNAI1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.76485 View
ENSG00000161547 SRSF2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.7648 View
ENSG00000071794 HLTF ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.764641 View
ENSG00000106993 CDC37L1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.764345 View
ENSG00000014216 CAPN1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.764018 View
ENSG00000162434 JAK1 ENSG00000204389 HSPA1A H. sapiens SSL Slorth 0.763791 View
ENSG00000076944 STXBP2 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.76372 View
ENSG00000162434 JAK1 ENSG00000178188 SH2B1 H. sapiens SSL Slorth 0.763465 View
ENSG00000162434 JAK1 ENSG00000167216 KATNAL2 H. sapiens SSL Slorth 0.763353 View
ENSG00000116489 CAPZA1 ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.762444 View
ENSG00000111640 GAPDH ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.762334 View