LEF1

ENSG00000138795 - H. sapiens

Pathways

Go term Description
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0030284 estrogen receptor activity
GO:0030331 estrogen receptor binding
GO:0035326 enhancer binding
GO:0042393 histone binding
GO:0042826 histone deacetylase binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0045295 gamma-catenin binding
GO:0070016 armadillo repeat domain binding
GO:0070742 C2H2 zinc finger domain binding

Drugs

No drugs in record

Diseases

Disease Name
B-ALL
T-ALL
eyelid sebaceous carcinoma
AML
lymphomas

Orthologs

Gene Organism
pop-1 C. elegans
pan D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000010810 FYN ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.933306 View
ENSG00000138795 LEF1 ENSG00000175387 SMAD2 H. sapiens SDL Slorth 0.933163 View
ENSG00000082701 GSK3B ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.931847 View
ENSG00000135446 CDK4 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.931786 View
ENSG00000138376 BARD1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.931413 View
ENSG00000100030 MAPK1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.929004 View
ENSG00000066468 FGFR2 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.928644 View
ENSG00000100029 PES1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.928463 View
ENSG00000127511 SIN3B ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.927924 View
ENSG00000112062 MAPK14 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.927833 View
ENSG00000136930 PSMB7 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.926779 View
ENSG00000138795 LEF1 ENSG00000198668 CALM1 H. sapiens SDL Slorth 0.925135 View
ENSG00000131759 RARA ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.924963 View
ENSG00000106588 PSMA2 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.924213 View
ENSG00000072401 UBE2D1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.923783 View
ENSG00000124762 CDKN1A ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.923712 View
ENSG00000103275 UBE2I ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.923674 View
ENSG00000138795 LEF1 ENSG00000197299 BLM H. sapiens SDL Slorth 0.923266 View
ENSG00000100387 RBX1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.923088 View
ENSG00000102882 MAPK3 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.922384 View
ENSG00000129559 NEDD8 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.921855 View
ENSG00000138795 LEF1 ENSG00000221983 UBA52 H. sapiens SDL Slorth 0.921675 View
ENSG00000138795 LEF1 ENSG00000149273 RPS3 H. sapiens SDL Slorth 0.921001 View
ENSG00000062822 POLD1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.920582 View
ENSG00000134086 VHL ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.920462 View
ENSG00000104365 IKBKB ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.920419 View
ENSG00000121022 COPS5 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.919936 View
ENSG00000112592 TBP ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.919745 View
ENSG00000129084 PSMA1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.919429 View
ENSG00000110395 CBL ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.919154 View
ENSG00000138795 LEF1 ENSG00000161057 PSMC2 H. sapiens SDL Slorth 0.918132 View
ENSG00000113721 PDGFRB ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.917386 View
ENSG00000101361 NOP56 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.915686 View
ENSG00000108443 RPS6KB1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.914402 View
ENSG00000096717 SIRT1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.913992 View
ENSG00000078140 UBE2K ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.913431 View
ENSG00000138795 LEF1 ENSG00000175104 TRAF6 H. sapiens SDL Slorth 0.913242 View
ENSG00000138795 LEF1 ENSG00000143799 PARP1 H. sapiens SDL Slorth 0.912965 View
ENSG00000012048 BRCA1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.91272 View
ENSG00000096717 SIRT1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.911777 View