LEF1

ENSG00000138795 - H. sapiens

Pathways

Go term Description
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0030284 estrogen receptor activity
GO:0030331 estrogen receptor binding
GO:0035326 enhancer binding
GO:0042393 histone binding
GO:0042826 histone deacetylase binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0045295 gamma-catenin binding
GO:0070016 armadillo repeat domain binding
GO:0070742 C2H2 zinc finger domain binding

Drugs

No drugs in record

Diseases

Disease Name
B-ALL
T-ALL
eyelid sebaceous carcinoma
AML
lymphomas

Orthologs

Gene Organism
pop-1 C. elegans
pan D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000079999 KEAP1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.82359 View
ENSG00000113712 CSNK1A1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.823439 View
ENSG00000096384 HSP90AB1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.821778 View
ENSG00000121481 RNF2 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.818862 View
ENSG00000110713 NUP98 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.815703 View
ENSG00000108424 KPNB1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.813923 View
ENSG00000130939 UBE4B ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.813912 View
ENSG00000100028 SNRPD3 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.813743 View
ENSG00000115524 SF3B1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.813254 View
ENSG00000138069 RAB1A ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.812945 View
ENSG00000092201 SUPT16H ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.812256 View
ENSG00000110330 BIRC2 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.809696 View
ENSG00000061938 TNK2 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.809142 View
ENSG00000070831 CDC42 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.8037 View
ENSG00000138795 LEF1 ENSG00000166501 PRKCB H. sapiens SSL Slorth 0.803238 View
ENSG00000114062 UBE3A ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.80068 View
ENSG00000115816 CEBPZ ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.800052 View
ENSG00000132646 PCNA ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.80005 View
ENSG00000087586 AURKA ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.798811 View
ENSG00000138795 LEF1 ENSG00000164885 CDK5 H. sapiens SSL Slorth 0.796444 View
ENSG00000100138 SNU13 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.795601 View
ENSG00000096968 JAK2 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.795328 View
ENSG00000138795 LEF1 ENSG00000168283 BMI1 H. sapiens SSL Slorth 0.794975 View
ENSG00000058729 RIOK2 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.788745 View
ENSG00000114503 NCBP2 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.786867 View
ENSG00000138795 LEF1 ENSG00000150459 SAP18 H. sapiens SSL Slorth 0.786628 View
ENSG00000138795 LEF1 ENSG00000283094 PTEN H. sapiens SSL Slorth 0.78602 View
ENSG00000101161 PRPF6 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.785615 View
ENSG00000047315 POLR2B ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.78207 View
ENSG00000138795 LEF1 ENSG00000158402 CDC25C H. sapiens SSL Slorth 0.781508 View
ENSG00000005007 UPF1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.780658 View
ENSG00000080815 PSEN1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.778351 View
ENSG00000049759 NEDD4L ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.77674 View
ENSG00000138795 LEF1 ENSG00000165731 RET H. sapiens SSL Slorth 0.774374 View
ENSG00000099956 SMARCB1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.771913 View
ENSG00000109332 UBE2D3 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.770755 View
ENSG00000104738 MCM4 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.769794 View
ENSG00000138795 LEF1 ENSG00000185359 HGS H. sapiens SSL Slorth 0.769721 View
ENSG00000131508 UBE2D2 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.769634 View
ENSG00000099804 CDC34 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.768897 View