LEF1

ENSG00000138795 - H. sapiens

Pathways

Go term Description
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0030284 estrogen receptor activity
GO:0030331 estrogen receptor binding
GO:0035326 enhancer binding
GO:0042393 histone binding
GO:0042826 histone deacetylase binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0045295 gamma-catenin binding
GO:0070016 armadillo repeat domain binding
GO:0070742 C2H2 zinc finger domain binding

Drugs

No drugs in record

Diseases

Disease Name
B-ALL
T-ALL
eyelid sebaceous carcinoma
AML
lymphomas

Orthologs

Gene Organism
pop-1 C. elegans
pan D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000112062 MAPK14 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.967459 View
ENSG00000109320 NFKB1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.966471 View
ENSG00000138795 LEF1 ENSG00000185591 SP1 H. sapiens SDL Slorth 0.965591 View
ENSG00000138795 LEF1 ENSG00000173039 RELA H. sapiens SDL Slorth 0.964387 View
ENSG00000110092 CCND1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.962325 View
ENSG00000138795 LEF1 ENSG00000168610 STAT3 H. sapiens SDL Slorth 0.961252 View
ENSG00000138795 LEF1 ENSG00000166167 BTRC H. sapiens SDL Slorth 0.960132 View
ENSG00000138795 LEF1 ENSG00000162385 MAGOH H. sapiens SDL Slorth 0.959793 View
ENSG00000138795 LEF1 ENSG00000183207 RUVBL2 H. sapiens SDL Slorth 0.959508 View
ENSG00000137154 RPS6 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.958343 View
ENSG00000138795 LEF1 ENSG00000170312 CDK1 H. sapiens SDL Slorth 0.957773 View
ENSG00000100644 HIF1A ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.9568 View
ENSG00000132383 RPA1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.955833 View
ENSG00000101146 RAE1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.955225 View
ENSG00000135486 HNRNPA1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.953226 View
ENSG00000082701 GSK3B ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.953075 View
ENSG00000138795 LEF1 ENSG00000164924 YWHAZ H. sapiens SDL Slorth 0.952736 View
ENSG00000100028 SNRPD3 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.951373 View
ENSG00000100906 NFKBIA ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.950779 View
ENSG00000115524 SF3B1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.950395 View
ENSG00000101266 CSNK2A1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.949885 View
ENSG00000122406 RPL5 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.948296 View
ENSG00000112592 TBP ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.94717 View
ENSG00000097046 CDC7 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.944582 View
ENSG00000082898 XPO1 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.944046 View
ENSG00000101868 POLA1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.943929 View
ENSG00000136997 MYC ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.942899 View
ENSG00000113575 PPP2CA ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.942488 View
ENSG00000004700 RECQL ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.941619 View
ENSG00000138795 LEF1 ENSG00000169375 SIN3A H. sapiens SDL Slorth 0.941389 View
ENSG00000041357 PSMA4 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.939773 View
ENSG00000114166 KAT2B ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.938595 View
ENSG00000111276 CDKN1B ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.938183 View
ENSG00000138795 LEF1 ENSG00000141646 SMAD4 H. sapiens SDL Slorth 0.937112 View
ENSG00000132383 RPA1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.936452 View
ENSG00000135341 MAP3K7 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.936427 View
ENSG00000132155 RAF1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.936301 View
ENSG00000123374 CDK2 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.935146 View
ENSG00000097007 ABL1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.934096 View
ENSG00000087191 PSMC5 ENSG00000138795 LEF1 H. sapiens SDL Slorth 0.933718 View