LEF1

ENSG00000138795 - H. sapiens

Pathways

Go term Description
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0030284 estrogen receptor activity
GO:0030331 estrogen receptor binding
GO:0035326 enhancer binding
GO:0042393 histone binding
GO:0042826 histone deacetylase binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0045295 gamma-catenin binding
GO:0070016 armadillo repeat domain binding
GO:0070742 C2H2 zinc finger domain binding

Drugs

No drugs in record

Diseases

Disease Name
B-ALL
T-ALL
eyelid sebaceous carcinoma
AML
lymphomas

Orthologs

Gene Organism
pop-1 C. elegans
pan D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000010810 FYN ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.875722 View
ENSG00000073111 MCM2 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.875201 View
ENSG00000114767 RRP9 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.874814 View
ENSG00000126261 UBA2 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.874602 View
ENSG00000135624 CCT7 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.874591 View
ENSG00000135018 UBQLN1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.873697 View
ENSG00000110092 CCND1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.873596 View
ENSG00000101966 XIAP ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.870093 View
ENSG00000128245 YWHAH ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.867725 View
ENSG00000117399 CDC20 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.867469 View
ENSG00000117676 RPS6KA1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.864515 View
ENSG00000280548 FBL ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.862888 View
ENSG00000136238 RAC1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.862216 View
ENSG00000136937 NCBP1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.861531 View
ENSG00000102882 MAPK3 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.860594 View
ENSG00000091831 ESR1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.860411 View
ENSG00000123124 WWP1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.860351 View
ENSG00000004897 CDC27 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.860113 View
ENSG00000078747 ITCH ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.858775 View
ENSG00000110107 PRPF19 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.857597 View
ENSG00000117748 RPA2 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.854231 View
ENSG00000082898 XPO1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.854182 View
ENSG00000135446 CDK4 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.853485 View
ENSG00000109320 NFKB1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.85251 View
ENSG00000137693 YAP1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.850548 View
ENSG00000138795 LEF1 ENSG00000187608 ISG15 H. sapiens SSL Slorth 0.848735 View
ENSG00000112118 MCM3 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.845665 View
ENSG00000121774 KHDRBS1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.844666 View
ENSG00000138795 LEF1 ENSG00000143190 POU2F1 H. sapiens SSL Slorth 0.843632 View
ENSG00000136518 ACTL6A ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.841859 View
ENSG00000124181 PLCG1 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.840118 View
ENSG00000093009 CDC45 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.835018 View
ENSG00000094804 CDC6 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.834448 View
ENSG00000102978 POLR2C ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.827791 View
ENSG00000103194 USP10 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.827354 View
ENSG00000132341 RAN ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.826256 View
ENSG00000036257 CUL3 ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.82597 View
ENSG00000136628 EPRS ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.825839 View
ENSG00000138795 LEF1 ENSG00000169045 HNRNPH1 H. sapiens SSL Slorth 0.825784 View
ENSG00000119048 UBE2B ENSG00000138795 LEF1 H. sapiens SSL Slorth 0.824597 View