TOP1MT

ENSG00000184428 - H. sapiens

Pathways

Go term Description
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor
TOPOTECAN DNA topoisomerase I, mitochondrial inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000143799 PARP1 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.96141 View
ENSG00000002016 RAD52 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.961083 View
ENSG00000105568 PPP2R1A ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.961056 View
ENSG00000100393 EP300 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.959615 View
ENSG00000100028 SNRPD3 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.957653 View
ENSG00000115524 SF3B1 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.957499 View
ENSG00000087191 PSMC5 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.957271 View
ENSG00000175104 TRAF6 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.956886 View
ENSG00000161057 PSMC2 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.956825 View
ENSG00000101361 NOP56 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.956739 View
ENSG00000136238 RAC1 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.955812 View
ENSG00000142208 AKT1 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.954948 View
ENSG00000175792 RUVBL1 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.952894 View
ENSG00000171720 HDAC3 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.95284 View
ENSG00000082898 XPO1 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.95198 View
ENSG00000097007 ABL1 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.95152 View
ENSG00000141510 TP53 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.951177 View
ENSG00000101266 CSNK2A1 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.950811 View
ENSG00000166949 SMAD3 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.950679 View
ENSG00000184428 TOP1MT ENSG00000188612 SUMO2 H. sapiens SDL Slorth 0.950546 View
ENSG00000147604 RPL7 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.950195 View
ENSG00000170312 CDK1 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.949989 View
ENSG00000145604 SKP2 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.949884 View
ENSG00000135486 HNRNPA1 ENSG00000184428 TOP1MT H. sapiens SSL Slorth 0.949528 View
ENSG00000080503 SMARCA2 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.949522 View
ENSG00000103035 PSMD7 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.948801 View
ENSG00000131876 SNRPA1 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.948793 View
ENSG00000106588 PSMA2 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.948202 View
ENSG00000108671 PSMD11 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.948152 View
ENSG00000126067 PSMB2 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.947968 View
ENSG00000137154 RPS6 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.94754 View
ENSG00000067560 RHOA ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.947 View
ENSG00000096717 SIRT1 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.945889 View
ENSG00000041357 PSMA4 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.945353 View
ENSG00000100519 PSMC6 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.944925 View
ENSG00000142541 RPL13A ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.944876 View
ENSG00000100906 NFKBIA ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.944611 View
ENSG00000099817 POLR2E ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.944482 View
ENSG00000140988 RPS2 ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.941726 View
ENSG00000184428 TOP1MT ENSG00000197299 BLM H. sapiens SDL Slorth 0.941084 View